As climate change and population growth raise the likelihood of natural disasters, it becomes crucial to comprehend and mitigate these risks in vital infrastructure systems, especially nuclear power plants (NPPs). This research addresses the necessity for evaluating multiple hazards by concentrating on slope failures triggered by earthquakes near NPPs over a timeframe extending up to a return period of 100,000 years. Utilizing a Geographical Information System (GIS) and Monte Carlo Simulation (MCS), the research conducts a comprehensive fragility assessment to predict failure probability under varying ground-shaking conditions. According to the Newmark displacement method, factors such as Peak Ground Acceleration (PGA), slope angle, soil properties, and saturation ratio play significant roles in determining slope safety outcomes. The investigation aims to enhance understanding seismic event repercussions on NPP-adjacent landscapes, providing insights into long-term dynamics and associated risks. Results indicate an increase in slope vulnerability with longer return periods, with distinct instances of slope failures at specific return periods. This analysis not only highlights immediate seismic impacts but also underscores the escalating risk of slope displacement across the extended return period scales, crucial for evaluating long-term stability and associated hazards near nuclear infrastructure.