This study investigated the life anxiety and current situation of Yanbian residents under the adjustment of China’s epidemic prevention and control measures, and analyzed 235 questionnaire data with SPSS23.0. The results of independent T-test based on demographic sociological characteristics show that residents' anxiety in villages about income security and living goods security is signific-antly higher than that of residents in cities; The drug security anxiety of the elderly was significantly higher than that of the young; The income security anxiety of the people with low educational level is significantly higher than that of the people with high educational level; The anxiety scores of economic income security, medical security and drug security of low-income groups were significantly higher than those of the control group; The gender difference is not obvious in all variables. The life satisfaction of the high-income group and the elderly group was significantly higher than that of the control group. In addition, economic income level, medical security and epidemic hazards significantly affect the life satisfaction of Yanbian residents. Therefore, all levels departme nts in Yanbian should provide targeted services for different groups of people, and improve the residents’ quality of life in Yanbian by implementing measures including promoting economic development, strengthening medical treatment capacity, and reducing epidemic hazards.