The limitation of markers for chronic oral diseases such as oral lichen planus (OLP) and burning mouth syndrome (BMS) is a diagnostic challenge for clinicians. The pathogenesis of OLP and BMS is not yet fully understood. Therefore, diagnoses are mainly based on the observation of clinical features and history, rather than established markers. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are used to determine the state of inflammation; however, these markers have some limitations. Recently, a new inflammatory marker, pentraxin-3 (PTX3), has been identified in other systemic inflammatory diseases. PTX3 is a member of the pentraxin family and is classified as a long pentraxin. PTX3 is found in various human tissues, whereas the classical short pentraxin, CRP, is secreted only in the liver. PTX3 is a marker of autoimmune diseases and periodontitis. However, there are no studies on PTX3 in OLP and BMS; therefore, we sought to determine if PTX3 can be a diagnostic marker for OLP and BMS. PTX3 was found to be correlated with other inflammatory markers, suggesting its diagnostic value for inflammatory oral diseases. We also found that the PTX3 levels were lower in patients with OLP and BMS. ESR levels were elevated in the OLP and BMS groups, but CRP levels were not. Despite these associations, no correlation was found between PTX3 expression and other known clinical features of OLP and BMS. We suggest that PTX3 plays a role in the immunological and neurological pathways involved in the complex pathogenesis of OLP and BMS.

PURPOSES : LED based Variable Message Signs(VMS) have been widely used to inform safety messages to the drivers in advance. Legibility Distance of VMS is the most important factor to provide the safety messages to drivers in timely and effective way. However, current National Standards on legibility distance design considers letter size only even there is a difficulty to read the signs at adverse weather conditions such as heavy fog. So, this study examined the legibility issue under fog by evaluating the legibility distance with two design factors such as letter size and luminance. METHODS : Two foggy weather conditions, intermediate and heavy fog, were simulated at real-road-scale Proving Ground. Legibility distance at daytime and nighttime was evaluated by test subjects. Subjects were asked to fill the legible distance on the test sheet and statistical significant was analysed at the lab. RESULTS : The legibility distance(LD) under fog was observed only 22 to 41% of LD observed under normal weather condition at daytime, and 26 to 45% at nighttime condition. Study results showed a consistent increase in LD with higher luminance even at same letter size and vice versa conditions, However, statically significant difference between groups was only revealed when both letter size and luminance level increased conditions. In order to apply the test results in terms of engineering benefits, LD results from significantly different groups was evaluated with relative to Stopping Sight Distance(SSD) within conceptual frame suggested in this study. CONCLUSIONS : From the study results, current National Standard on legibility distance design needs to consider letter size and luminance simultaneously to response the legibility issue in adverse weather conditions.

Radish is an important root vegetable in the world, and many cultivars have been developed with various molecular marker systems to identify these cultivars. Recently developed markers for radish cultivar identification require only 11 primer pairs, but they still use conventional PCR with different annealing temperatures and time-consuming gel electrophoresis. To improve the genotyping method, we applied touchdown PCR with 11 primers with M13 tails among 105 radish cultivars. Touchdown PCR successfully generated amplicons in all 11 M13-tailed primers with a condition of annealing temperature starting from 55℃, decreased by 1°C and 33 cycles at 53°C. The 11 M13-tailed primers followed by fragment analysis produced 71 amplicons, which produced more amplicons than gel electrophoresis that produced 23 amplicons. Especially, simple sequence repeats produced more amplicons, 12 on average, than the other marker types. The present study requires less effort and provides more accurate results compared to genotyping using gel electrophoresis. Besides, a database can be established using digitized genotyping results among radish cultivars.

PURPOSES : This study aims to examine actual cases of providing detour information in accidental situations such as traffic accidents and road construction through a VMS installed on national highways in metropolitan areas with alternative routes, as well as cases of simultaneously providing travel time information on parallel paths such as national and regular highways. For each case, we analyzed whether the provision of VMS traffic information leads to route changes and substantial effects. METHODS : To analyze traffic changes on the main and detour roads based on the detour information provided on traffic accidents in actual cases, the traffic volume and speed on the accident day were compared with those on the same days and at the same time of the day (regular days) based on the VDS data of the main and detour roads. Cases providing more detour information on road construction were investigated by examining three time periods: one week from construction initiation and one week before and after the construction period (regular days). The traffic volume and speed on the main road were compared based on the VDS data, and those on the detour road were compared based on data made available by private entities. Regarding the cases of simultaneously providing drivers with comparative information on travel time over parallel sections of national and regular highways, traffic situation changes in highways were analyzed in the following special traffic control periods (New Year's Day, NY Day), during which congestion is expected due to heavy traffic: before and after the provision of comparative information for 2015 New Year's Day and 2016 NY Day. RESULTS : The detour rate related to route changes based on the detour information for traffic accidents was 35%. On the detour route, the traffic volume increases as traffic from the main road is absorbed. However, the average travel speeds did not differ significantly. When further detour information regarding a road construction project was provided, the detour rate from the main road was 21%. The travel speeds were similar, except on the first day of construction. Almost no changes were observed in the first section of the detour. The speed slightly decreased in the second section but did not significantly hinder the traffic flow. When comparative traffic time information on parallel routes (national highways and expressways) was provided, the traffic volume increased to some extent after the report was provided for every case. However, the data frequency rate in the 5-min unit, which was still under the congestion speed standard (40 km/h), decreased. This indicates that traffic congestion was significantly relieved. CONCLUSIONS : Previous studies on detour rates or route changes based on VMS traffic information have focused on VMS instruments on expressways. Although their estimates were based on simulated situations, this study used actual VMS installed on national highways. In addition, this study utilizes the existing case records of national highway ITS centers, covering traffic situation monitoring, measures for accidental situations, etc., in regular times or special traffic control periods, as well as statistical data, including ITS real-time traffic information. The analysis results of this study accurately represent situations on actual roads and can be utilized to analyze future ITS operation and installation project effects.

우리나라 해양생태계의 현황을 조사 및 분석하여 해양을 지속하게 이용할 수 있도록 하며 해양생태를 보전하고 관리할 수 있 도록 국가 해양생태계 종합조사를 해양수산부의 위탁을 받아 해양환경공단에서 진행하고 있다. 국가 해양생태계 종합조사는 주요 조사정 점을 설정하여 한반도 주변 해역의 생태계 변화를 조사하고 있지만, 정점이 연안을 중심으로 설정되어 근해역 등 조사범위 확대가 필요 한 실정이다. 한편 해양수산부 항로표지과에서는 항로표지 인양점검 시 부착생물의 사진을 촬영하여 제공함으로써 국가 해양생태계 종합 조사를 지원하고 있지만, 해양환경공단과 협의하여 지정된 등부표에 한해서 부착생물 사진을 제공한다. 이에 항로표지를 국가 해양생태 계 종합조사의 정점으로 활용할 수 있도록, 항로표지 및 등부표 인양점검 시 딥러닝 기반의 영상처리 알고리즘을 활용하여 부착생물의 정보를 생성하는 연구를 진행했다. 항로표지를 국가 해양생태계 종합조사의 정점으로 활용한다면 항로표지의 활용 가치를 제고하고 우리 나라 근해의 이상 해황 및 생태계 변화를 분석할 수 있는 기초자료로 활용할 수 있다.

PURPOSES : Speed management is essential for enhancing children’s safety in school zones. The objectives of this study are to analyze how digital-based school zone signs and newly proposed signage for increasing visibility influence speed reductions and how the new system facilitates drivers obeying the speed limits. METHODS : A before/after analysis technique with comparison groups (widely used to evaluate safety effects) was employed. To effectively capture the safety effects of the new system, two significant measures were selected as the measures of effectiveness: the rates of change in space mean speeds and speed limit compliance. RESULTS : With three target sites and three comparison sites, the mean space speeds after installing the new systems were found to be slightly reduced for all target sites (the reduction rates of the space mean speed were found to be 5% for site A, 1% for site B, and 6% for site C). The lack of a constant tendency in speed reduction effects at all sites might be owing to the fact that the speed data collection was conducted before the driver's system adaptation was sufficiently performed. Regarding the speed limit compliance rate, significant increases were observed at two sites (10% for site A and 51% for site C), but site B did not show an increasing effect. The reason for the absence of this effect is that the installation of crosswalks and speed bumps at the target site affected the driver's compliance with the speed limit. CONCLUSIONS : An insufficient amount of evaluation results was obtained for the new guidance system. However, the new guidance system method provides an alternative approach to improving children's safety, i.e., by inducing drivers to actively slow down in school zones.

항로표지는 항행하는 선박에 대하여 가항수역의 위치·방향 및 장애물의 위치 등을 알려주는 항행보조시설이다. 항로표지가 가 항수역의 한계를 표시할 때에는 해당 수역을 처음 이용하는 항해자의 입장에서 편리하게 이용할 수 있도록 배치되어야 한다. 우리나라의 서남해안에는 지형적인 영향으로 많은 수의 좁은 수로가 형성되어 있으며, 좁은 수로를 따라 IALA 해상부표식에 따른 측방표지 및 방위 표지 등이 배치되어 있다. 본 연구는 우리나라 서남해안 좁은 수로에 배치된 항로표지가 양식장 개발 등의 해상교통 환경 변화 이후, 선 박운항 안전에 대한 역할을 제대로 수행하고 있는지 검토한 실증 사례 연구이다. 서남해안의 5가지 좁은 수로에 대한 사례 검토 결과, 항 로표지가 표시하는 가항수역 상에 양식장이 분포하여 항로표지로서의 역할을 제대로 수행하지 못하는 것으로 나타났다. 본 연구의 결과 로, 해당 항로표지의 종별 혹은 위치 변경, 양식장 표지의 설치, 해도상 양식장 위치 표기 등의 개선방안을 제시하였다.

In this study, a mixed resin containing Bis-GMA was developed to produce a light-emitting sign using quantum dots. As a result of measuring the viscosity, color coordinates change, and luminance of the mixed resin, the following conclusions were obtained. The viscosity of the mixed resin decreased as the content of the diluent increased, and viscosity values ​​ranged from 3,627 to 1,349cps showed as a result. The viscosity of the mixed resin decreased as the temperature increased, and the viscosity showed a value of 5,156 to 1,132cps. For the optical properties of InP/GaP/ZnSe/ZnS quantum dots, the absolute quantum efficiency was 91% at 522nm and 90% at 618nm when the gallium was 0.01%. The luminance of the light-emitting sign using the resin mixed with quantum dots was showed 142.6cd/m2 in white and 104.2cd/m2 in the red region.

This investigation aims to identify the roles of the discourse marker ja in home shopping discourse. In 12 excerpts of home s hopping d iscourse, ja h as been f ound 8 6 times, u sed as a marker o f adding more information, changing a subject, starting a new topic, focusing and suggesting. The analysis showed that the adding more information function, which is the most frequently used one (35 times), and the suggesting one were newly found in this type of discourse and directly related to the characteristic of the discourse: show hosts tend to provide as much information about the product as possible and to justify the consumption by suggesting various reasons. In addition, cases in which ja was used more than two times by one speaker were often found, which is connected to the fact that it is necessary to keep consumers' attention for the purpose of selling products. Also, guests who occasionally appear to help the hosts never used ja, which is because only show hosts have the power to control the discourse. In the process of switching the topic (e.g. price, composition, product features, or rushing comments), ja was used as a subject-changing marker second most frequently (29 times), especially when making rushing comments. These findings turn out to be closely related to the distinctive features of home shopping discourse, demonstrating the importance of studying discourse markers within the context of institutional discourse.

이 연구의 목적은 진안·무주 국가지질공원의 안내 표지판에 제시된 용어에 대한 학생들의 이해 정도를 알아보기 위한 것이다. 이를 위하여 학생 219명(초등학교 147명, 중학교 41명, 고등학교 31명)을 대상으로 지질공원에 대한 인식 수준, 안내 표지판의 유용성에 대한 인식, 그리고 국가지질공원에 설치된 안내판에 제시된 용어에 대한 이해 정도를 알아보기 위한 설문을 실시하였다. 이때 학생들의 용어에 대한 이해정도를 알아보기 위해 지질명소에 설치된 대표적인 안내 표지판 10개를 선정하고 전체 내용을 텍스트 형태로 변환하였으며, 전문가 3인과의 논의를 통해 핵심 용어 256개를 추출한 후 학생들에게 제시하여 이해 정도를 파악하였고, 이에 대한 결과는 다음과 같다. 첫째, 학생들의 지질 공원에 대한 인식 수준은 매우 낮은 것으로 나타나 이에 대한 홍보와 교육적 접근이 필요해 보인다. 둘째, 학생들은 안내판에 대해 흥미를 보이지 않았으며 내용이 많고 어려워 이해도가 낮은 것으로 나타났다. 셋째, 256개의 용어 중에서 학생들이 이해하기 어려워하는 용어의 수는 초등학생 80개, 중학생 53개, 고등학생 31개로 나타나 학교 급이 높아지면서 감소하는 경향을 보였다. 이때 용어를 이해하기 어려운 이유는 초등학생은 교육과정에서 아직 배우지 않은 용어이기 때문이며, 중·고등학생은 전문 용어와 한자어에 대한 이해의 어려움 때문인 것으로 나타났다. 따라서 지질공원의 안내 표지판은 학생 및 방문객들이 보다 이해하기 쉽도록 한자어를 쉽게 풀어 쓰거나 전문 용어에 대한 추가 설명이 필요할 것으로 보인다.

본고는 『베트남의 중국어 학습자들의 개사 말뭉치(코퍼스)』 (2018년판)를 토대로 초급 중국어 수준의 베트남 학습자들의 지속상 표지 ‘着’ 오류 현황을 고찰한다. 연구를 통해 학습자들의 오류가 ‘첨가’, ‘혼동’, ‘(필요 성분의) 누락’ 이라는 세 유형으로 귀납됨을 알아냈다. 그 결과 ‘첨가’가 가장 높은 비율을 차지하고 그 다음이 ‘혼동’ 오류이며, ‘(필요 성분의) 누락’ 이 가장 낮은 비율을 차지하는 오류 유형을 알 수 있었다. 목적어 규칙의 지나친 일반화가 이러한 오류들 의 주요 원인이었다. 필자는 이를 기반으로 교학에 대한 몇 가지 의견을 제시하려고 한다.

최근에 감에서 떫은맛을 조절하는 AST에 연관된 지역에서 분자 표지들이 개발되었다. 이중에서 sequence characterized amplified region (SCAR) marker는 5R region에 인접한 지역에서 개발되었다. 하지만 이 SCAR마커는 분석 방법이 다소 복잡하고 해석이 어려워 많은 교배실생을 분석할 경우에는 적합하지 않다. 우리는 5R 지역의 sequences에 기반하여 high-resolution melting (HRM)-based 분자 표지를 개발하였다. 개발된 HRM preimer set을 8개 품종의 단감 및 떫은감에 대해 적용한 결과 단감 품종에서는 직선을 나타낸 반면 떫은감 품종에서는 다양한 크기의 곡선으로 나타나서 차이를 확인할 수 있었다. 결과적으로 이번 연구에서 개발된 HRM primer set은 분자 표지를 활용한 감 품종 육성 연구에 매우 효율적으 로 활용될 수 있을 것으로 기대된다.