The purpose of this study is to analyze two greek prepositions (‘apo’ and ‘se’) and learners’ errors to suggest comprehensible instruction in general. To express spatial meaning, the Greek language uses almost exclusively combinations of local adverbs with prepositions, especially ‘apo’ and ‘se’, with certain case while the Korean language uses ‘adverbial particles’. The first investigation is to look into the meanings of greek prepositions, especially ‘apo’ and ‘se’ which are ‘primary’ prepositions in the Greek language. It is necessary to analyze how they are expressed in the Korean language due to set instructional direction to Korean learners. There are many adverbial particles which correspond with each meaning of two greek prepositions so that it is not that clear for Korean learners to understand scattered semantic category of each preposition. Subsequently we will analyze learners’ errors of their use of prepositions. The result shows that the learners are problematic to use ‘apo’ and ‘se’ properly. In some cases their use of the prepositions seems mixed up. It is important to know problematic points of greek prepositions ‘apo’ and ‘se’ to Korean learners to set some efficient instruction. At the conclusion, there are some suggestions on the effective teaching of greek prepositions ‘apo’ and ‘se’ especially in ‘complex prepositions’ using images and example sentences.