The purpose of this study is to compare the correlation of clinical characteristics and patterns of disease. Subjects of the study were the adults(207) living in Geoje City, the diabetes mellitus and the hypertension patients(166) and the normal people(41). In the diabetes mellitus group and the hypertension group, blood pressure, blood glucose, total cholestero LDL-cholesterol and atherogenic index(AI) were significantly high. As the obesity index was getting higher, the blood pressure of the diabetes mellitus group was high, and the HDL-cholesterol of the hypertension group was low, but AI of it was significantly high. The AI was significantly high as serum lipid index were getting higher in both groups. The rate of the prevalence was very high in the diabetes mellitus group(74.3%) and the hypertension group(73.7%). The pattern in the diabetes mellitus group was in order of the hypertension, the hyperlipidemia, and the obesity but, in the hypertension group was the hyperlipidemia, and the obesity. The obesity index and serum lipid index of complex patient group were higher than single patient group.

충청북도 청주시 흥덕구에 거주하고 있는 24명의 독거 노인 (남자 10명, 여자 14명)으로 당뇨병 환자이고 경계성 고혈압 이상에 해당되며, 60세 이상인 노인을 대상으로 혈압과 혈청학적인 검사를 실시하여 얻은 결과는 다음과 같다. 1. 수축기 혈압은 3주에 1주보다 A군에서는 4.9% 상승하였고 B군은 0.3%가 증가되었으며 C군에서는 5.9%가 감소되었다. 각 군의 3주 평균은 A군 158.3±24.3, B군 149.1±19.2, C군 143.9±5.1로 C군, B군, A군 순으로 통계적으로 유의하게 낮은 것으로 나타났다. 이완기 혈압은 1주에 비해 3주에 A군에서는 3.7% 증가하였고 B군은 0.3% 감소하였으며 C군에서는 1.5% 증가하였다. 각 군의 3주 평균은 A군 93.8±11.3, B군 93.2±11.2, C군 86.9±6.2로 C군, B군, A군 순으로 낮게 나타났다. 이 결과에 의하면 두릅음료가 수축기와 이완기 혈압 조절에 기여하는 것으로 보인다. 2. 혈당은 3주에 1주보다 A군에서는 0.5%가 증가하였고 B와 C군에서는 각각 13.9%와 17.5%가 감소되어 두릅음료가 혈당저하에 효과적인 것으로 나타났다. 3. 중성지방은 1주에 비해 3주에 A군에서 11.6% 증가되었고 B군에서는 5.0% 감소하였으며 C군에서는 3.8%가 증가되었다. 총콜레스테롤은 1주보다 3주에 A군에서는 2.3% 증가되었고 B와 C군에서는 각각 8.7%와 14.5%가 감소하였다. HDL-콜레스테롤은 A와 B군에서는 각각 4.8%와 13.2%가 낮아졌고 C군에서는 19.6%가 증가되었으며 LDL-콜레스테롤은 1주보다 3주에 A군에서 1.9% 상승하였으나 B와 C군에서는 각각 8.3%와 21.1%가 저하되었다. 이 실험 결과에 의하면 두릅음료가 총 콜레스테롤과 LDL-콜레스테롤 저하와 HDL-콜레스테롤 증가에 효과적인 것으로 나타났고 중성지방의 조절에는 효과적이지 못한 것으로 나타났다. 4. GOT는 3주에 1주에 비해서 A군은 16.4% 감소하였고 B군은 14.9% 증가하였으며 C군은 14.7%가 저하되었다. GPT는 3주에 1주보다 A군 1.0%, B군 43.0%, C군은 43.0%의 증가를 나타내었다. 총 빌리루빈은 3주에 1주에 비해 A군에서는 변화가 거의 없었고, B군에선 25% 감소를 보였으며 C군은 50%가 증가되어 GOT, GPT 및 총 빌리루빈의 농도는 두릅음료에 의해 저하되지 않는 것으로 나타났다. 5. 총 단백질은 3주째 1주보다 A군은 13.6%, B군은 8.6%, C군은 11.8%가 증가되었고 알부민은 3주째 1주에 비해 A와 C군은 증가가 없었고, B군에서만 11.6% 감소하였으며 혈중요소질소는 1주보다 3주에 A와 B군은 각각 6.3%와 14%가 감소되었고 C군에서는 2.2%가 증가되었으며 요산은 3주에 1주보다 A와 C군에서 각각 20.4%와 11.1%가 감소하였고 B군에서만 14.3%가 증가하여 두릅음료의 효과가 총 단백질, 알부민, 혈중요소질소 및 요산에서는 뚜렷하게 나타나지 않았다.

The aim of the experiments was to investigate the effect of Fructus Tribuli on the blood pressure, plasma renin activity, plasma levels of aldosterone and atrial natriuretic peptide (ANP) in spontaneously hypertensive rats (SHR). The results of this study were as follows: 1. Systolic blood pressure decreased significantly after the administration of Fructus Tribuli water extract 0.03 ㎖/200 g. 2. Plasma renin activity and plasma levels of aldosterone were not changed after the administration of Fructus Tribuli water extracts. 3. Plasma levels of atrial natriuretic peptide (ANP) decreased significantly after the administration of Fructus Tribuli water extracts.

Lactic acid bacteria (LAB) are industrially important microorganisms for probiotics. The recent widespread application of LAB for preparation of functional food is attributable to the accumulating scientific evidence showing their beneficial effects on human health. In this study, we isolated and characterized plant-derived LAB that show angiotensin-converting enzyme (ACE) inhibitory and antioxidant activities. The selected strain K2 was isolated from Kimchi, and identified as Lactobacillus plantarum by 16S rRNA gene analysis. The strain grew under static and shaking culture systems. They were also able to grow in different culture conditions like 25℃∼37℃ temperature, 4∼10 pH range and ∼6% NaCl concentration. L. plantarum K2 was highly resistant to acid stress; survival rate of the strain at pH 2.5 and 3 were 80% and 91.6%, respectively. The strain K2 also showed high bile resistance to 0.3% bile bovine and 0.3% bile extract with more than 74% of survival rate. The cell grown on MRS agar plate containing bile extract formed opaque precipitate zones around the colonies, indicating they have bile salt hydrolase activity. The strain showed an inhibitory activity against pathogenic bacteria such as Escherichia coli, Staphylococcus aureus and Listeria monocytogenes; antibacterial activity was probably due to the lactic acid. The K2 strain showed relatively higher autoaggregation values, antihypertensive and antioxidant activities. These results suggest that L. plantarum K2 could be not only applied as a pharmabiotic for human health but also is also starter culture applicable to fermentative products.

Styela clava tunic is generated in large amounts as a waste from S. clava processing plants and leads to environmental problems. It destroys the beach scenery and causes a bad smell and pollution by trashing on the seashore. Therefore, purpose of this study was to investigate antioxidant and antihypertensive activities of different solvent extracts from S. clava tunic for recycling of fishery waste. Antioxidant and antihypertensive activities of all extracts were concentration-dependent. Of extracts, hot water extract showed the highest DPPH radical scavenging activity with the lowest effective concentration (EC50) value (0.733 mg/ml). Chloroform extract exhibited the highest metal chelation activity with the lowest EC50 value (2.696 mg/ml). Autoclaved water extract showed the highest NO radical scavenging activity with the lowest EC50 value (0.491 mg/ml) and n-hexane extract showed the highest reducing power (A700=1.897 at 100 mg/ml). And n-butanol extract showed the highest SOD-like activity with the lowest EC50 value (19.116 mg/ml) and ACE inhibition activity with the lowest inhibitory concentration(IC50) value (0.149 mg/ml). These results indicate that extracts obtained from S. clava tunic may potential candidate to reduce diseases caused by various oxidative stresses and hypertension.

The Ambulatory arterial stiffness index (AASI) and abnormal dipping patterns have been suggested as a risk factor for stroke. Recent studies have reported that AASI might be confounded by dipping patterns as a prognostic marker. We conducted a retrospective analysis of the data of 869 hypertensive patients for evaluation of the association of stroke with AASI and dipping patterns. AASI was higher in patients with stroke than in patients without stroke (0.47±0.16 vs. 0.41±0.17; p=0.083) and inversely related with nocturnal systolic BP reduction (r=–0.21; p<0.001). In multiple linear regression analysis, independent predictors of AASI were 24-hour pulse pressure (β= 0.447, p<0.001) and nocturnal dipping (β=–0.178, p<0.001). The odds ratio (OR) for stroke associated with AASI was 0.86 (95% confidence interval (CI), 0.29–2.5; p=0.777) after multivariate adjustment. Higher OR was observed for non-dippers, extreme-dippers, and reverse-dippers than for dippers (OR 1.57; 95% CI 1.02–2.4, p=0.04, OR 2.71; 95% CI 1.06–6.88, p=0.037, OR 2.56; 95% CI 1.56–4.2, p<0.001, respectively). The results of this study show that dipping pattern has a stronger association with stroke than AASI in patients with hypertension.

괴경 내부에 적색과 보라색 안토시아닌 색소가 풍부하게 함유되어 있고, 색상의 기호도 및 건강 기능성으로 인해 소비자로부터 기호도가 증대된 유색감자의 생리적 활성을 검토하기 위해 유색감자의 대조구로 괴경 내부가 백색인 수미 품종을 사용하고, 유색감자로서 괴경 내부가 적색인 대관 1-102호, 괴경 내부가 보라색인 자심품종과 대관 1-104호로 구분하여 항산화, 활성산소 소거능 및 항고혈압 활성을 비교, 검토한 결과는 아래와 같다. 1. 유색감자 추출물의 항산화 활성 검정결과 추출물의 농도가 10ug/mL 수준에서는 유색감자별 차이를 나타내지 않았으나, 50ug/mL 을 처리한 경우 시료 간 차이를 뚜렷하게 나타내었으며, 유색감자 중 괴경내부의 색상이 적색인 대관 1-102호가 34%의 높은 저해율을 나타내어 30%의 저해율을 나타낸 활성평가 대조구인 α-tocopherol 보다 높은 항산화 활성을 나타내었다. 2. 유색감자 추출물의 자유 라디칼 소거 활성에서는 괴경 내부가 보라색인 대관 1-104호가 50%의 소거능을 나타내는 농도가 9.83ug/mL 로 가장 높은 라디칼 소거활성을 나타내었으며, 이 결과 또한 대조시약인 α-tocopherol 이나 BHT보다 높은 소거 활성을 나타내었다. 3. 유색감자 추출물의 xanthine oxidase 활성 억제효과를 검토한 결과 유색감자 간에 큰 차이를 나타내어 대관 1-102호와 1-104호의 경우 xanthine oxidase 활성을 50% 저해하는 데 필요한 농도는 약 26ug/mL 수준으로 가장 높게 조사되었으며, 다음으로 수미(46ug/mL ), 자심(49ug/mL )의 순으로 조사되었다. 4. 유색감자 추출물의 ACE 저해 활성을 검토한 결과 항고혈압 대조구 활성물질인 captopril의 수준에는 미치지 못하나 유색감자 간에는 명확한 차이를 나타내었다. 괴경내부색상이 적색인 대관 1-102호가 117.7ug/mL 으로 가장 높은 ACE 저해 활성을 나타내었으며, 내부색상이 보라색인 대관 1-104호와 자심은 130ug/mL 로 유사한 양상을 나타내었으며, 괴경내부 색상이 백색을 나타내는 수미품종은 192ug/mL 으로 가장 낮은 활성을 나타내었다. 5. 이상의 결과를 종합해 볼 때 괴경 내부에 적색 혹은 보라색 안토시아닌을 다량 함유한 유색감자는 기존 백색을 가진 일반감자에 비해 항산화, 자유레디칼 소거활성 및 항고혈압 활성이 높고, 시각적 식미감을 증대시키므로 유색감자는 기능성이 증대된 식용감자로서의 이용가치가 충분한 것으로 판단된다.

Wished to measure and analyzes blood pressure change of that walk forest walking path to woman among slight illness hypertensive who move into silver town and when walked asphalt walking path so that this study searches positive effect about that it so that may recognize widely positive side through that walk for blood pressure coercion of hypertensives exercise do and walks in forest exercise and clear benefit of forest walking path. Through this study, proved study finding is as following. 1) Exercise to walk estimates distance more than minimum 1200m that can see positive effect though do exercise. 2) According to result that blood pressure change of asphalt walking path and forest walking path does comparative analysis, significance probability was recognized at systolic blood pressure, and change of blood pressure was recognized significance probability at systolic blood pressure after exercise on the forest walking path. 3) Result that woman old man and slight illness high blood pressure old man woman blood pressure does comparative analysis, forest walking path after exercise in contraction period, relaxation period blood pressure significance probability recognize. These result estimates by thing which it can maximize effect of exercise that walk on the forest walking path that do exercise. 4)Appeared by thing which synonymy is between sequence, two circles that emotion state on forest walking path and asphalt walking path does comparative analysis, and change of emotion state was recognized significance probability in the most articles after forest walking path exercise. This can judge kinetic effect that keep emotion state that can maximize in case of do exercise on the forest walking path. This studies are giving effect that walk exercise is positive in old man woman's body, but examines closely that the floor was displaying effect that was surrounded by the tree than hard asphalt walking path and walks on forest walking path of soft earth road exercise is positive in body and confirmed necessity of forest walking path.

GABA차를 본태성 고혈압 쥐에 음용시켰을 때, 1.5% GABA차가 포함된 먹이를 섭취한 본태성 고혈압 쥐의 3주 후 수축기 혈압은 처음의 175.53mmHg에 비해 177.35mmHg로 별 차이가 없었으나 대조구는 192.06mmHg로 수축기 혈압이 상당히 증가함을 볼 수 있었다. 혈장 중 aldosterone 농도도 GABA차 1.5% 섭취 쥐는 248.56±30.44pg/ml인데 반해 대조구는 606.98±57.79pg/ml로 2.5배 이상 농도 수준이 낮음을 알 수 있었다.