to malignant transformation. Oral leukoplakia is a common premalignant lesion in oral mucosa and the incidence of cancer progression into SCC has been reported to be 0~43%. The genetic alterations of oncogenes, tumor suppressor genes and DNA repair genes occur during carcinogenesis. In order to evaluate the role of epithelial cells in the early stage of carcinogenesis, we analyzed the alterations of genetic heterogeneity in epithelial cells of oral leukoplakia samples, using Laser capture microdissection(LCM). The incidence rate of microsatellite instability(MSI) and loss of heterozygosity(LOH) were analysed from the DNA of epithelial cells from 16 leukoplakia samples using adjacent fibroblasts as a normal control. In this study, LOH was found in epithelial cells of all 16 cases of leukoplakias while MSI has been observed in 3 cases. Interestingly, the fibroblasts showed LOH and MSI in some cases, which was confirmed by DNA sequencing. Taken together, this study showed that leukoplakia has multiple genetic alterations in fibroblasts as well as in epithelial cells, suggesting that interaction between epithelial cells and fibroblasts might be involved in the early step of carcinogenesis.

전통적으로 Cordyceps종은 한국을 포함한 동양에서 건강증진과 심장과 폐에 관련된 질환을 치료하는 약용식물의 하나로 사용되어왔다. 최근에 동충하초의 약리적 가치 때문에 큰번데기 동충하초를 포함한 몇가지 Cordyceps종의 인공재배에 관한 연구가 활발하게 이루어지고 있다. 본 연구에서는 큰번데기 동충하초를 in vitro에서 인공재배한 결과 자실체 형성이 불안정한 것을 관찰하였기에 보고하고자 한다.

요통은 산업화된 현대사회에서 흔히 발생하는 질환이다. 요통의 다양한 원인 중에서도 척추의 정상 가동범위를 넘은 불안정성이 요통의 한 원인으로 보고되고 있다. 이 문헌고찰의 목적은 요추 부위의 안정성을 부여하는 운동 프로그램 후 근육 기능의 강화, 통증의 감소를 보고한 논문들을 비교, 분석하는 것이다. 그리하여 요통의 한 원인인 척추의 안정성을 증가시켜 요추 부위의 통증을 감소시키고 기능을 향상시키는 운동 프로그램의 효과를 입증하는 것이다.

Shell structure that is best used for the long span structure is a structure which can effectively resist against the external load. But these structure has instability like snap-through and bifurcation buckling, and it has a characteristic sensitive to the initial conditions. Therefore, to determine the analysis model of DDOF Space Truss and when the beating load was applied in model, we confirmed the changing results for height and load.

In this study, a structural modeling and an analysis considering structural stability were investigated to develop an icosahedron-based hemispherical modular dome. To design the dome, a program that can perform icosahedron shape modeling, modularization of joint connection members. Furthermore, based on the adopted numerical model, the buckling mode, unstable behavior characteristics according to load vector, and the critical buckling load of the modular dome under uniformly distributed load and concentrated load were analyzed, and the resistance capacities according to different load vectors were compared.

The purpose of this study is to analyze the results of treatment of unstable intertrochanteric fractures with compression hip screw and wiring. Twenty one cases of intertrochanteric fractures of the 20 patients treated with compression hip screw and wiring between January 2009 and December 2013 were analyzed. Twenty cases were united and the mean union time was 17.5 weeks. The results of treatment of unstable trochanteric fractures with compression hip screw were relatively satisfactory.