The purpose of this study was to test that motor skill training enhance motor function and cerebellar development. Using an animal model of fetal alcohol syndrome-which equates peak blood alcohol concentrations across developmental period-critifical periods for the effect of alcohol on body and cerebellar weigh was examined. The effect of motor skill training on motor function and cerebellar development of rat exposed alcohol on postnatal days 4 through 10 were studied. Newborn rats were assigned to one of two groups: (1) Control group (CG), via artificial rearing to milk formula and (2) experimental groups (EG), via 4.5g/kg/day of ethanol in a milk solution. After completion of the treatments, the pups were fostered back to lactating dams, and wearing they were raised in standard caged until they were postnatal 48 days. Rats from experimental group of postnatal treatment then spent 10 days in one of two groups: Experimental group II (EGII) was had got motor skill training (training traverse a set of 6 elevated obstacles) for 4 weeks. Experimental group I (EGI) was not trained. Before sacrificing, the rat got examined two behavioral test, body weigh and cerebellar weigh, then coronal sections were processed. The section was investigated the Purkije cell in the cerebellum using light microscope. The results of this study were as follows. 1. In body weight test, the outcome of alcohol groups were significantly lower than the normal group. 2. In cerebellar weight test, the outcome of EGI were significantly lower than CG and EGII. 3. In motor behavioral test, the outcome of EGI was significantly lower than NG and EGII. 4. In Purkinje cells counting test, the outcome of EGI was significantly lower than the NG and EGII. These result suggest that improved motor function induced by motor skill training after postnatal exposure is associated with dynamically altered expression of Purkinje cells and that is related with cerebellar function. Also, these data can potentially serve as a model for therapeutic intervention.

This study was designed to investigate the effects of treadmill exercise of low-intensity and moderate- intensity on the functional recovery and histological change in spinal cord injury (SCI) rats. SCI was induced by the spinal cord impactor dropped after laminectomy. Experimental groups were divided into the Group I (normal control), Group II (non-treatment after SCI induction), Group III (low-intensity treadmill exercise after SCI induction), Group IV (moderate-intensity treadmill exercise after SCI induction). After operation, rats were tested at modified Tarlov scale at 2 days with divided into 4 groups, and motor behavior test (BBB locomotor rating scale, Grid walk test) was examined at 3, 7, 14, and 21 days. For the observation of damage change and size of the organized surface in spinal cord, histopathological studies were performed at 21 days by H & E, and BDNF(brain-derived neutrophic factor) & Trk-b immunohistochemistry studies were performed at 1, 3, 7, 14, 21 days. According to the results, treadmill exercise can play a role in facilitating recovery of locomotion following spinal cord injury. Specially, moderate-intensity treadmill exercise after SCI induction was most improvement in functional recovery and histological change.

목적 : 강제유도운동치료가 뇌졸중 환자의 상지 기능 및 일상생활활동의 수행 능력에 미치는 효과를 알아보는 것이었다.연구방법 : 연구 대상은 뇌졸중으로 인한 편마비 진단을 받은 3인이었으며 개별실험 연구방법(single-subject experimental research design) 중 ABA 설계를 사용하였다. 강제유도운동치료는 12일 동안 팔걸이와 보조기로 건측을 깨어있는 시간의 84.9% 동안 억제하고, 6시간 동안 환측을 집중적으로 치료하는 방법으로 실시하였다. 대상자의 상지 기능은 기초선 과정(5회)과 치료 과정(12회), 기초선 회귀 과정(5회) 동안 상자와 나무토막 검사 그리고 수직선 그리기 검사를 사용하여 측정하였다. 일상생활활동의 수행 능력은 강제유도운동치료 전․후에 Assessment of Motor and Process Skills(AMPS)를 사용하여 측정하였다. 결과 : 대상자의 상지 기능은 기초선 기간보다 치료 기간 동안에 현저히 향상되었으며 이 향상은 기초선 회귀 과정 동안에도 계속 지속되었다. 일상생활활동의 수행 능력은 대상자 3인 중 2인에서 유의하게 향상되었다. 결론 : 강제유도운동치료는 뇌졸중으로 인한 편마비 환자의 환측 상지 기능을 향상시키는데 효과적이며, 우세손이 환측인 대상자들의 일상생활활동의 수행 능력을 향상시키는 것으로 나타났다. 앞으로의 연구에서는 많은 뇌졸중 환자를 대상으로 강제유도운동치료가 일상생활활동에 미치는 영향에 대하여 우세측과 비우세측에 따른 환측 부위를 고려한 분석이 이루어져야 할 것이며, 강제유도운동치료 효과의 지속성에 대해서 연구되어야 할 것이다.

The aim of this study was to investigate the effect of abdominal drawing-in maneuver (ADIM) on peak exploratory flow (PEF), forced exploratory volume in 1 second (FEV1), and low back pain during forced expiration. Twenty-two subjects (14 subjects in experimental group, 8 subjects in control group) participated in this study. The stabilizer was used for ADIM training for five consecutive days. Vitalograph PEF/FEV1 DIARY and visual analogue scale (VAS) were used to determine forced expiratory pulmonary function and low back pain, respectively. Independent t-test and analysis of covariance were used for statistical analysis with a significance level of .05. The findings of this study were as follows: 1) There were no significant differences of ADIM effect on PEF and FEV1 between experimental group and control group. 2) There was a significant pain reduction in experimental group with ADIM. 3) PEF and FEV1 increased significantly in the fifth day compared with the first day pre-exercise baseline. Therefore, it is concluded that ADIM was effective in improving PEF and FEV1, and reducing VAS during forced expiration in patients with chronic low back pain.

목적 : 만성기 편마비 환자에서 상지 운동기능 회복을 위한 기능적 전기자극의 효과를 알아보고자 하였다. 연구방법 : 신경학적으로 더 이상의 회복을 기대할 수 없는 발병 후 12개월 이상이 경과된 만성기 편마비 환자 18명을 대상하였다. 편마비측에 4주 동안 전기자극 치료의 적용 없이 기능의 변화를 평가하였고, 이후 4주간은 전기자극 치료를 1회 20분, 1일 1회, 주 5일간 마비측 상지에 적용하여 기능의 변화, 동작을 분석하였다. 전기자극은 수지의 파악, 주관절의 굴곡, 주관절의 신전, 수지의 이완 등의 순서로 식사동작을 모방하여 작동되도록 조작하였다. 상지의 기능회복정도를 측정하기 위하여 수지 근력, 상지의 근력 측정과 Fugl-Meyer 운동기능 평가를 실시하였고, 인지 및 지각능력을 평가하였으며, 정량 분석을 위하여 삼차원 동작 분석기(CMS10 measuring system)를 이용하여 상지의 동작을 분석하였다. 결과 : 전기자극을 적용하기 전에서는 편마비측 수지 및 상지의 근력과 Fugl-Meyer 운동기능에서 유의한 변화가 없었으며, 기능적 전기자극을 적용한 경우에 치료 전에 비해 치료 후에 편마비측 견관절과 주관절의 굴곡, 완관절의 신전 근력이 증가하였으며, 수지 근력, Fugl-Meyer 운동기능 평가에서 유의한 호전이 관찰되었다(p<.05). 삼차원 동작 분석기를 이용한 상지 기능의 평가에서 회내-회외운동 동작에서 진폭과 진동수의 유의한 증가가 보였으며, 변이도의 유의한 감소가 관찰되었다. 검지 두드리기와 손바닥 두드리기 동작에서는 진동수의 유의한 증가와 변이도의 유의한 감소가 관찰되었다(p<.05). 결론 : 발병 후 12개월 이상이 경과된 만성기 편마비 환자에서 마비측 상지에 대한 기능적 전기자극 치료는 상지 운동기능의 호전에 유의한 효과를 보였다.

목적 : 본 연구에서는 뇌졸중 환자에게 손상측 손의 주먹 쥐기 동작을 실시하여 동측 경상 운동 발현 유무를 확인하고, 동측 경상 운동과 손상측 상지 기능의 관계를 비교해 보고자 하였다. 연구방법 : 2개의 전자 악력계를 이용하여 손상측 손으로 대상자가 할 수 있는 최대의 힘으로 주먹 쥐기를 10초 동안 유지하는 것을 시행한 후 동측 경상 운동을 측정하고, 동측 경상 운동의 유무에 따라서 경상 운동이 나타나는 환자군 15명과 경상 운동이 나타나지 않는 환자군 15명으로 구분하였다. 경상 운동의 유무에 따른 손상측상지의 기능을 비교하기 위해서 퍼글-마이어 평가, 퍼듀 페그보드 검사, 악력 측정을 실시하였다. 결과 : 동측 경상 운동이 나타나는 환자군과 경상 운동이 나타나지 않는 환자군의 집단 간의 손상측 상지 기능의 비교에서 퍼글-마이어 평가, 퍼듀 페그보드 검사, 악력 모두에서 통계학적으로 유의한 차이를 보였다(p<.05). 동측 경상 운동이 나타나는 환자군이 경상 운동이 나타나지 않는 환자군보다 상지의 전반적인 기능에서 좋지 않은 것으로 나타났다. 결론 : 뇌졸중 이후에 나타나는 동측 경상 운동은 상지 기능에 좋지 않은 영향을 미치는 것을 알 수 있고, 운동 결함이 있는 동측 경상 운동이 나타나는 환자에서 뇌졸중 이후 회복 과정의 임상적 양상을 알 수 있다. 따라서 뇌졸중 환자의 평가와 치료에 있어서 동측 경상 운동을 고려해야 하며, 앞으로 뇌졸중 환자에서 경상 운동의 지속적인 평가와 치료적 중재에 관한 연구가 필요할 것이다.

목적 : 본 연구의 목적은 편마비 아동에게 수중에서 시행하는 대칭운동이 상지기능에 미치는 영향을 알아보는데 있다. 연구방법 : 연구의 대상자는 뇌병변으로 인한 좌측편마비 진단을 받은 8세 아동이었다. 본 연구는 개별사례 실험 연구방법 중 반전연구(ABA)를 사용하였으며, 각각 8회기의 기초선 과정, 치료기간, 그리고 치료 후 관찰기간 동안 상지기능을 평가하였다. 상지기능의 평가는 Bruininks-Oseretsky 운동기능 발달검사 소항목인 동전 옮기기와 Grooved 페그보드 검사를 통하여 이루어졌다. 또한 팔뻗기 과제에 대한 동작분석은 치료기간 전과 후에 각각 측정되었다. 대상자는 치료선 과정과 치료 후 관찰기간에는 일반적인 물리치료 및 작업치료를 받았으며, 치료기간에는 이에 더하여 40분간의 수중 대칭운동을 추가로 시행하였다. 결과 : 동전 옮기기와 페그보드 검사로 평가된 상지기능은 기초선과정보다 치료기간 동안에 향상되었으며, 이는 치료 후 관찰기간에도 지속적으로 유지되었다. 팔뻗기 과제에 대한 동작분석 결과 치료기간 후에 과제 완료시 체간의 굴곡 보상이 감소되었으며 견관절의 굴곡과 주관절의 신전이 움직임이 증가되었다. 또한 견관절과 주관절의 움직임 형태가 안정적으로 변하였다. 결론 : 수중 대칭운동은 편마비 아동의 상지 기능 및 움직임의 향상에 긍정적인 영향을 미칠 수 있다. 향후에는 많은 대상자들을 포함하고 장기간 시행된 연구가 계속적으로 이어져야 할 것이다.

The purpose of this study was to assess the effect of a group self exercise program in improving the quality of life regarding depression and the activities of daily living (ADL) of chronic stroke survivors, as well as the motor functions such as the 3 meter round walk, upper extremity function, and static balance. The subjects were 12 post-stroke ambulatory community center participants. All subjects participated in one 90 minute session per week for 7 weeks and received a home exercise program in every session. They had to record and submit an exercise check list. Quality of life was measured with the Beck depression inventory and the 8-Item Short-Form (SF-8). Motor functions were measured with the manual function test (MF'T), the kinesthetic ability trainer (KAT 3000), and the modified Barthel index. The level of depression decreased somewhat, but there were no significant differences after intervention. However, quality of life related health (SF-8) improved significant1y. There were significant improvements in the time for the 3 meter round walk, the functions of the affected upper extremities, and static balance and ADL (p<.05). The findings of this study suggest that a group self exercise program can improve quality of life related health and motor functions in stroke survivors.

Environmental Enrichment (EE) alone is not capable of enhancing the fine digit and the forelimb functions. Therefore, we applied modified constraint-induced movement therapy (mCIMT) under the influence of EE to assess its effect on promoting improved forelimb sensorimotor functions. Focal ischemic brain injury was produced in Sprague-Dawley rats (60 rats, 250±50 g) through middle cerebral artery occlusion (MCAO). Before MCAO induction, all rats were trained in modified limb placing tests and reaching tasks for 1 week. Then they were randomly divided into three groups: Group I: application of standard environment (SE) after MCAO induction (n=20), Group II: application of EE after MCAO induction (n=20), Group III: MCAO+EE, mCIMT and task-oriented training that was initiated at 10th day after MCAO induction (n=20). We also applied mCIMT (between 9 AM and 5 PM/daily) which included restraining the forelimb ipsilateral to the lesion using the 'Jones & Schallert' method. We assessed the change of modified limb placing, single pellet reaching test and the immunoreactivity of BDNF by immunohistochemistry (pre, 1st, 5th, 10th and 20th day). Group I showed no improved outcome, whereas group II and III significantly improved on the use of the forelimb and the immunoreactivity. The qualitative analysis of the skilled reaching test, of group III showed the greatest improvement in the fine digit and the forelimb function. These results suggest that EE combined with mCIMT is more functional in promoting enhanced fine digit and forelimb functional movements.

Although many children with cerebral palsy have problems with their eye movements available data on its intervention is minimal. The purpose of the study was to determine the effectiveness of the postural movement normalization and eye movement program on the oculomotor ability of children with cerebral palsy. Twenty-four children with cerebral palsy (12 male and 12 female), aged between 10 and 12, were invited to partake in this study. The subjects were randomly allocated to two groups: an experimental group received the postural movement normalization and eye movement program and a control group which received conventional therapy without the eye movement program. Each subject received intervention three times a week for twelve weeks. The final measurement was the ocular motor computerized test before and after treatment sessions through an independent assessor. Differences between the experimental group and control group were determined by assessing changes in oculomotor ability using analysis of covariance (ANCOVA). The changes of visual fixation (p<.01), saccadic eye movement (p<.01) and pursuit eye movement (p<.01) were significantly higher in the experimental group than in the control group. These results show that the postural movement normalization and eye movement program may be helpful to treat children with cerebral palsy who lose normal physical and eye movement.

The purpose of this study was to improve the professional's development of skill in qualitative analysis of humanMovement fromthe various subdisciplines of physical education. The conclusions were as follows; First, Physical educators and coaches can impr

The purpose of this study was to determine the consequence of resistance strengthening exercise on the hip flexor and extensor performed to improve functional mobility in stroke patients more than six months post stroke. Seventeen patients were randomized into two groups. Both groups received conventional physical therapy for six weeks. In addition, the experimental group performed eccentric resistance strengthening exercise in the hip flexor and extensor using an isokinetic dynamometer. The hip flexor and extensor strength, stair up and down mobility, timed get up and go (TUG), 10 m gait velocity, and functional reach were repeatedly measured at baseline, three weeks, and six weeks after treatment. The results were as follows: 1. The experimental group improved more remarkably in the hip flexor and extensor strength, stair up and down mobility, and the 10 m gait velocity after three weeks and six weeks of treatment (p<.05), 2. The control group improved significantly in the hip flexor and extensor strength, and 10 m gait velocity after three weeks of treatment (p<.05), 3. At each three and six week point, the experimental group made greater gains in hip flexor and extensor strength, stair up and down mobility, and 10 m gait velocity than the control group (p<.05). In conclusion, it is desirable to perform resistance strengthening exercises combined with conventional physical therapy to improve functional mobility in chronic stroke patients.

The aim of this study was to assess the effectiveness of group therapeutic exercise programs on the cognitive function, Activities of Daily Living (ADL), and balance-performing ability in older adults. Fifteen community-dwelling subjects (mean age 73.7 yrs, standard deviation 2.4) participated in this study. An 8-week group therapeutic exercise program, including strengthening and balance training, breathing and gait exercise, and recreation, consisted of activities related to daily living. The Mini-Mental State Examination-Korean (MMSE-K), Modified Barthel Index (MBI), Berg Balance Scale (BBS), Functional Reaching Test (FRT), and Timed Up & Go (TUG) test were measured during pre-exercise and post-exercise points. The results of this study were as follows: 1. After eight weeks, the MMSE-K and MBI total score was more significantly increased for post-exercise tests than pre-exercise tests (respectively, p<.05, p<.01). 2. Of the MBI contents, personal hygiene, dressing, ambulation, and chair/bed transfers scores were significant increased for post-exercise tests. 3. Post exercise BBS, FRT, and TUG scores were higher than the pre-exercise scores. The difference was statistically significant (respectively, p<.05, p<.05, p<.01). These findings suggest that group therapeutic exercise can be used to improve the cognitive function, ADL, and balance-performing ability in elderly persons.

The purposes of this study were to test that complex motor training enhance motor function significantly, to test change in cerebellum, and to test the synaptic plasticity into the immunohistochemistry response of synaptophysin. Using an animal model of fetal alcohol syndrome - which equates peak blood alcohol concentrations across developmental period - the effects of alcohol on body weight during periods were examined. The effect of complex motor training on motor function and synaptic plasticity of rat exposed alcohol on postnatal days 4 through 10 were studied. Newborn rats were assigned to one of two groups: (1) normal group (NG), via artificial rearing to milk formula and (2) alcohol groups (AG), via 4.5 g/kg/day of ethanol in a milk solution. After completion of the treatments, the pups were fostered back to lactating dams, where they were raised in standard cages (two-and three animals per cage) until they were postnatal 48 days. Rats from alcohol group of postnatal treatment then spent 10 days in one of two groups: Alcohol-experimental group was had got complex motor training (learning traverse a set of 6 elevated obstacles) for 4 weeks. The alcohol-control group was not trained. Before consider replacing with "the experiment/study", (avoid using "got" in writing) the rats were examined during four behavioral tests and their body weights were measured, then their coronal sections were processed in rabbit polyclonal antibody synaptophysin. The synaptophysin expression in the cerebellar cortex was investigated using a light microscope. The results of this study were as follows: 1. The alcohol groups contained significantly higher alcohol concentrations than the normal group. 2. The alcohol groups had significantly lower body weights than the normal group. 3. In alcohol groups performed significantly lower than the normal group on the motor behavioral test. 4. In alcohol-control group showed significantly decreased immunohistochemistric response of the synaptophysin in the cerebellar cortex compared to the nomal group. These results suggest that improved motor function induced by complex motor training after postnatal exposure is associated with dynamically altered expression of synaptophysin in cerebellar cortex and that is related with synaptic plasticity. Also, these data can potentially serve as a model for therapeutic intervention.

목적 : 뇌성마비가 아닌 발달장애로 진단된 아동을 대상으로 GMFM과 BSID-Ⅱ 평가를 각각 실시한 후 GMFM이 BSID-Ⅱ의 하위 항목들과 상관관계가 있는지 알아봄으로써 발달장애 아동의 평가도구로써 활용가능성을 검증하고자 한다. 연구방법 : 연구의 대상은 인하대학부속병원 재활의학과에서 뇌성마비 이외의 발달장애로 진단받은 만 3세 이하의 아동 26명을 대상으로 GMFM과 BSID-Ⅱ를 평가하였다. 대상자들의 특성에 따라 조산의 유무, 출생시 체중, 역연령에 따라 구분한 후 각 집단간 차이 및 두 평가도구의 상관관계를 알아보았다. 결과 : 발달장애 아동 26명 중 조산의 유무와 출생시 체중에 따라 각 집단간 GMFM, BSID-Ⅱ 정신척도, BSID-Ⅱ 운동척도의 점수를 비교한 결과 유의한 차이가 없었으며, 교정연령에 따른 집단에서만 유의한 차이가 있었다(p<0.05). 또한 집단간 GMFM과 BSID-Ⅱ 정신척도는 조산아(r=0.68), 만숙아(r=0.67), 저체중아(r=0.63), 평균체중아(r=0.72)에서 모두 상관관계가 있었으며, GMFM과 BSID-Ⅱ 운동척도도 조산아(r=0.57), 만숙아(r=0.89), 저체중아(r=0.65), 평균체중아(r=0.90)에서 모두 상관관계가 있었다. 전체 아동의 GMFM과 BSID-Ⅱ 정신척도의 상관계수는 0.71, GMFM과 BSID-Ⅱ 운동척도의 상관계수는 0.84로 관계가 있었으며, 교정연령 상 하위집단에서 0.56-0.85로 상관관계가 있었다. 결론 : 본 연구의 결과를 볼 때 발달장애 아동의 GMFM과 BSID-Ⅱ의 평가 결과는 모두 뚜렷한 상관관계를 나타내었으며, 발달장애 아동의 운동기능을 평가하는데 있어 GMFM의 적용가능성을 보여주는 기초 자료가 될 것으로 사료된다.

목적 : 본 연구를 통하여 뇌손상으로 인한 편마비 아동들에게 10주 동안 적용된 수정된 강제유도 운동치료가 환측 상지의 운동․감각능력 및 일상생활에서의 환측 상지 사용 빈도에 미치는 효과를 알아보고자 하였다. 연구방법 : 본 연구는 개별사례 실험 연구 방법 중 반전연구(reversal design or ABA design)로 설계되었으며, 서울장애인종합복지관에서 뇌병변으로 인한 편마비 진단을 받고 재활치료 중인 4명의 아동을 대상으로 17주간 실시되었다. 총 17주의 연구기간은 3주간의 기초선 1기간, 10주간의 치료 적용기간, 4주간의 기초선 2기간(치료후 관찰기간)으로 이루어져 있다. 치료 기간 동안 대상 아동들에게 주 5회, 하루 5시간동안 강제유도 운동치료를 적용하였다. 치료 전․후의 환측 상지의 기능을 평가하기 위해 두점 인식능력과 모노필라멘트를 사용한 촉각 검사, 멜버른 검사를 실시하였고, Motor Activity Log(MAL) 중 아동에게 적용 가능한 20항목을 발췌한 부모작성일지를 사용하여 환측 상지 사용빈도를 측정하였다. 결과 분석을 위하여 대상자별로 측정된 상지의 운동 및 감각기능과 일상생활에서 환측 상지 사용 빈도의 평균값을 기술 통계적으로 제시하고 시각적 그래프를 통하여 기초선, 치료기간과 치료 후의 차이를 비교하였다. 결과 : 수정된 강제유도 운동치료 후 편마비 아동의 상지 운동 및 감각기능과 일상생활에서의 환측 상지 사용 빈도가 치료 전에 비해 향상되었고, 이러한 치료 효과는 치료종료 후 1개월까지 유지되었다. 결론 : 본 연구 결과는 장시간의 건측 상지 운동 제한에 따른 거부감으로 인해 아동에게 적용하기 어려웠던 기존 강제유도 운동치료의 문제점을 개선한 수정된 강제유도 운동치료는 적용시간을 각 아동의 특성에 맞게 조절하여 활용한다면 임상 재활치료에서 편마비 아동의 기능회복에 효과적으로 적용될 수 있을 것으로 기대된다.

The purpose of this study was to investigate the effect of Modified Constraint-Induced Therapy (MCIT) on the effected upper extremity of children with hemiparesis. Four children with hemiparetic upper extremity caused by brain injuries were trained by MCIT for ten weeks. During the same period, all of the subjects were also involved in thirty-minute regular physical therapy and occupational therapy. During the treatment period, the unaffected upper extremities of the subjects were restrained by a specially designed hand splint or a mitten for five hours a day, five days per week. For two hours out of the five-hour restraint period, the affected upper extremities were intensively trained by performing various functional tasks, which were individually structured to emphasize use of the affected arm. A single-subject design with A-B-A reversal was employed in this study. The affected limb motor ability was evaluated by Melbourne Assessment, measuring the time to grasp and release nine pegs, and measuring grasping power. As a consequence of this study, the affected limb motor test scores of all four subjects in the baseline period were improved during the treatment period. Furthermore, the treatment effect was maintained during a one-month follow-up period. The results of this study support the assumption that MCIT is an effective therapeutic method to improve the sensory and motor abilities of hemiparetic children. It also increases the frequency of functional use of the hemiparetic hands of brain-injured children. Based on the results of this study, it can also be assumed that the modified CIT method is especially beneficial to these children by reducing the negative emotional effects of forceful restraint of the unaffected upper extremity. To optimize the functional recovery of the paretic upper extremity by CIT, the restriction period per day should be decided individually, according to the characteristics of the individual.

We investigated the activation of the cerebral cortex during active movement, passive movement, and functional electrical stimulation (FES), which was provided on wrist extensor muscles. A functional magnetic resonance imaging study was performed on 5 healthy volunteers. Tasks were the extension of right wrist by active movement, passive movement, and FES at the rate of .5 Hz. The regions of interest were measured in primary motor cortex (M1), primary somatosensory cortex (SI), secondary somatosensory cortex (SII), and supplementary motor area (SMA). We found that the contralateral SI and SII were significantly activated by all of three tasks. The additional activation was shown in the areas of ipsilateral S1 (n=2), and contralateral (n=1) or ipsilateral (n=2) SII, and bilateral SMA (n=3) by FES. Ipsilateral M1 (n=1), and contralateral (n=1) or ipsilateral SII (n=1), and contralateral SMA (n=1) were activated by active movement. Also, Contralateral SMA (n=3) was activated by passive movement. The number of activated pixels on SM1 by FES ( pixels) was smaller than that by active movement ( pixels) and nearly the same as that by passive movement ( pixels). Findings reveal that active movement, passive movement, and FES had a direct effect on cerebral cortex. It suggests that above modalities may have the potential to facilitate brain plasticity, if applied with the refined-specific therapeutic intervention for brain-injured patients.