Perineural invasion (PNI) is the underestimated metastatic pathway and has been widely recognized as a negative prognostic factor in many human cancers. L1CAM is one of members of the immunoglobulin-like cell adhesion molecule (CAM) family, which play a role in neural development. Moreover, a new role of L1CAM outside the nervous system has been revealed. Overexpression of L1CAM was involved in the tumor progression and LN metastasis in various malignancies. In the present study, presence of PNI and L1CAM expression were examined to define their prognostic values in OSCC. In addition, association of L1CAM expression with presence of PNI was assessed to define the value as a candidate molecule supporting the diagnosis of PNI. We found that presence of PNI significantly correlated with LN metastasis and advanced clinical stage. L1CAM expression also significantly correlated with differentiation, lymph node metastasis, advanced clinical stage, as well as presence of PNI. Our results suggest that L1CAM seems to play a role in tumor progression, possibly through the PNI-related mechanism and could be a molecular marker for supporting the presence of PNI and predicting clinical outcome in OSCC.

본 연구는 전북 서해안권 국가지질공원 지질명소의 안내 표지판에 기술된 용어를 분석하였다. 안내 표지판에 기술된 용어들 중 명사만을 추출하여 표준국어대사전, 지구과학 학술용어집, 2015개정 교육과정에 따른 교과용 도서 개발을 위한 편수 자료를 기준으로 등재 여부를 확인하여 8가지 유형으로 분류하였다. 추출된 용어 중 71개(10.8%)의 용어는 어느 용어집에도 등재되지 않은 [유형 8]에 해당하는 용어들이었다. 이 유형의 용어들은 대부분이 [명사]+[명사] 또는 [명사]+[접사]가 결합하여 파생된 합성어로 그 의미를 명확하게 해석하여 이해하기란 쉽지 않은 것으로 판단되었다. 또한 256개(46%)의 용어가 전문 분야에서 사용되는 전문 용어로 확인되었다. 따라서 국가지질공원 안내 표지판의 제작에 있어 일반인들과 학생들이 더 쉽게 읽고 이해할 수 있도록 전문 용어를 가급적 쉽게 풀어서 기술하고 전문 용어를 사용할 경우에는 용어에 대한 주석을 달아 부연 설명을 통해 충분한 교육적 효과를 얻을 수 있도록 해야 할 것이다.

PURPOSES: The objective of this study is to evaluate the shear and tensile strength properties of adhesive road studs in asphalt and concrete pavements. METHODS: The 300 mm×300 mm×50 mm rectangular specimens were fabricated using asphalt and concrete mixture for installation of road studs. Four 140-mm-radius circular areas were milled on each specimen with depth of 5 mm to install the adhesive road studs. About 100 g of thermal melting adhesive was applied on the milled area, and then the road stud was bonded onto the surface of the asphalt and concrete mixture. Direct shear testing was conducted at a speed of 5 mm/min on the interface between road stud and asphalt and concrete materials. Tensile strength testing was also conducted on the prepared specimens by applying load with increase of 50 kPa per second. These tests were performed not only in dry condition but also in wet condition to determine the effect of moisture on the shear and tensile strengths. RESULTS : According to the shear testing results, the average shear strength of asphalt samples in dry and wet conditions are 0.509 and 0.234 MPa, respectively. From this testing, the shear strength of wet sample was found to be decreased by 50% with respect to that of the dry sample. Similar trends can be observed on the concrete samples. The average tensile strength of asphalt samples was 0.187 MPa at 1.5 mm of displacement in dry condition. The concrete sample has a 0.222 MPa average tensile strength, which is slightly higher than that of the asphalt sample because of the rough surface characteristics of the concrete sample. CONCLUSIONS: It is determined from this study that the shear and tensile strengths of road stud bonded on the surface of asphalt mixture are slightly lower than those on concrete samples. Regardless of the pavement type, the wet conditioning of the sample can decrease the shear and tensile strength by 50% those of the dry sample. In the future, the quality improvement of adhesive and increase of specific surface area should be considered to improve the bonding property between road stud and pavement surface.

PURPOSES: The objective of this study is to develop an external lighting traffic sign system for better visibility. METHODS: To develop an external lighting traffic sign system, we selected an installation location and an appropriate angle of view for the luminaire. Using these parameters, we developed an external traffic sign system based on field installation results on the lighting and reflector. The economic benefit is then compared with the cost, an analysis that is necessary for both internal and external lighting traffic signs. RESULTS: Through experiments on the number of luminaires necessary to improve illuminance deviation and visibility, it was confirmed that the illuminance was improved roughly 2 to 3 times by the use of two luminaires. The protruding height (H) of the luminaire is 1.0 m, in consideration of the differences in brightness and driver visibility between the top and bottom, and the angle of view of the luminaire is applied at 120 degrees of high-brightness and low-brightness difference. The lower illuminance is lowered because of the diffusion of light according to the angle of view of the luminaire, due to the longer protruding length of the external lighting type traffic sign. To improve from this problem, the experiment was performed with the application of the reflecting plate, the lower illuminance of the sign was lowered, and the upper and lower illuminance ratio was improved. This solution was confirmed to be effective. As a result of reviewing the economic feasibility of the external illuminated traffic sign system, the cost reduction effect was determined to be about 39.8%. CONCLUSIONS: The results of this study were used to develop a balanced combination of the optimum housing and lighting installation angle for external lighting traffic signs. The use of this technology requires further research under various site conditions.

사용자를 360°로 둘러싼 VR 환경은 콘텐츠에 대한 몰입도를 높여준다. 그리고 HMD를 사용할 때 디스플레 이를 통해 볼 수 있는 Field of view(FOV)가 넓을수록 몰입감이 넓어진다. 하지만 사용자가 사람 또는 그래픽 시스템의 FOV에 의해서 360° 환경을 한번에 인식할 수 없기 때문에 VR 환경에서 발생한 이벤트가 시야 밖 에 있다면 사용자는 인식 못할 수 있다. 이런 이벤트가 콘텐츠의 내러티브에 중요할 경우 사용자가 이를 인식할 수 있는 방법을 찾아야한다. 사람의 시야는 인식 가능한 정보가 각도에 따라 제한되므로 마커가 문자 또는 의미있는 형태 인 경우 사용자가 인식 할 수 있도록 화면 중앙에 위치해야 한다. 우리는 움직임에 대한 시각적 인지반응을 통해서 VR 환경에서 사용자에게 시야 밖의 정보를 제공한다. 우리는 고화질 콘텐츠 영상을 활용하기 위해서 EAC 영상을 활용하였다. Equi-angular cubemap(EAC)라 불리는 이 방법은 Cubemap 투영을 개선하여 왜곡을 줄이고 적도 영역에 할당되는 픽셀을 늘려서 질을 높이는 방법이다. 또 구형의 공통 투영면을 사용하고 유도 표지가 시간의 흐름에 따라 투영면을 따라 물결처럼 퍼지도록 하였다. 우리는 움직임을 가지는 약한 표지를 제안한다. 이 표지는 움직임에 대한 시각적 인지반응을 통해서 VR 환경에서 사용자에게 시야 밖의 정보를 제공한다. 이 유도 표지는 사용자의 몰입을 방해하지 않으며 중요 이벤트 또는 Point of interest(POI)에 대한 힌트를 사용자가 제공하며 HMD를 사용하는 VR에 적합하다.

PURPOSES : The purpose of this study is to find out how to perform a visual-based conjoint analysis of signs, specifically for those in subway systems. METHODS: To identify the current problems with signs, we conducted installation case studies on subway signs and developed visualized materials for survey. The visualized survey cards were used to record the subjects’preferences in the conjoint analysis. RESULTS: Based on the current problems of sign, we developed the profile cards and used the visualized survey cards to conduct the survey for conjoint analysis. From the conjoint analysis using the visualized survey cards, it was found that the values of Pearson’s R and Kendall’s tau are close to 1. This suggests that our model is a very fitted model for conjoint analysis. CONCLUSIONS: We concluded that a conjoint analysis of subway signs could be reliably performed by using visualized survey cards.

CVR은 실제 환경에서 파노라마 카메라를 이용해 영상을 촬영하여 만들 수 있어 컴퓨터 그래픽 또는 게임 엔진 등을 이용해서 가상환경을 새롭게 구성하지 않고 만들 수 있는 것이 장점이다. 근래 Google Cardboard와 같은 간이형 VR장치의 보급을 통해 사람들은 모바일 폰을 통해서 쉽게 VR을 접하게 되었고 특히 Facebook 또는 Google Youtube 와 같이 다양한 플랫폼들에서 제공하는 360° 영상 콘텐츠를 통해서 사용자는 다양한 CVR 체험을 즐길 수 있게 되었다. 하지만 사람의 제한된 시야 및 디스플레이 장치의 크기 등에 의해 사용자는 VR 환경의 일부분만 보게 된다. 게임의 경우에는 시야 밖의 중요한 적이나 환경 변화가 생길 경우 사용자가 이를 놓치지 않도록 UI나 아바타에 별도의 시각적 표지를 추가하여 사용자의 주의를 환기하지만 CVR에서는 이 방법을 적용하기 힘들다. 우리는 이 연구에서 사용자의 몰입을 방해하지 않으며 POI에 사용자의 포커스를 유도하기 위한 방법을 제안한다. 가상현실 내에서 POI로 부터 발생하는 Halo형태의 가이드 표지는 움직임에 대한 인지반응을 이용하여 CVR 환경에서 사용자의 포커스를 POI로 유도한다. 또한 이 방법은 사용자의 시선에 상관없이 POI를 기반으로 시각적 마커를 생성하므로 추가 메타 정보 및 시선 추적 없이 콘텐츠 이미지를 수정하여 CVR에 적용 할 수 있습니다.

Kim, Serom. 2018. “A Confrontational Discourse Marker I don't know”. The Sociolinguistic Journal of Korea 26(1). 83~109. The literal meaning of I don't know (hereafter IDN) references the speaker's insufficient knowledge about the topic at hand. However, in social interaction, speakers strategically use IDN in non-literal way to accomplish specific interactional goals. Preceding studies have mainly focused on analyzing the ‘avoiding functions’ of IDN in terms of how interactants use it to avoid disagreement or downgrade face-threatening acts. Little attention has been given to addressing the question of how IDN, as a discourse marker, is used in institutional contexts, particularly in news interviews where it is frequently used in responding turns. To address this lacuna, this study, from a conversation-analytic perspective, aims to analyze the interactional functions of IDN in political news interviews. The findings suggest that the confrontational functions of IDN are recurrently observed in the way the interviewee challenges the adversarial nature of questions or confronts the interviewer. In this respect, I propose four functional categories of IDN in regard to the interactional imports it has as a responsive uptake of the interviewer's questions: to confront the interviewer, to resist the terms and agendas of the questions, to disconfirm presuppositions, and to avoid aligning with preference favored by the design of the questions. Implications of the findings are noted with reference to their relevance to future research that approaches IDN as a discourse marker.

1. 전세계에서 식량문제 해결을 위해 다양한 식물 신품종들이 개발되고 있다. 이에 따라 식물 유전자원과 관련된 국내외 분쟁 또한 증가하고 있다. 2. 품종 분쟁 판결에 있어 재배시험, 물질분석 및 분자표지들이 근거로 제시되어 왔다. 그 중에서 유전적 분석 기법과 기능성 분자표지에 대한 연구가 신속성, 재현성, 기술 발달 등의 이유로 활발하게 적용되고 있다. 3. 국내외 7개의 분쟁 사례를 분석한 결과, 결정적인 증거자료로써 분자표지를 이용한 판별기술이 채택되고 있지는 않았다. 반면 목표 형질의 표현형 차이에 대한 재배시험의 통계적 자료가 더욱 결정적인 증거자료로 채택되고 있었다. 분자표지가 충분한 증거로써 채택되지 못하는 원인은 분자표지 제공자의 객관성과 증거로 제시된 표지가 품종의 결정적 차이를 보이는 목적 형질과 연결되지 않았기 때문이었다. 4. 형질과 연결되지 않는 분자표지 대신 유전자 발현표지나 기능성 분자표지를 개발하여 적용하는 것이 더 효율적이고 합리적이라 판단한다. 5. 분쟁에서 근거로써 분자표지의 단점을 보완하여 분쟁에 적용한다면 품종 분쟁에 있어 보다 효율적이고 객관적인 판정이 이루어질 수 있을 것이다.

Genotyping-by-sequencing (GBS) is a cost-efficient method which can be useful for SNP marker discovery in a population of interest. GBS is genome reduction sequencing method using restriction enzyme. The quality of DNA is a key factor which could have an influence in downstream analysis. However, there have not been many studies which investigated the impact of DNA degradation and the quality of the data on marker discovery. In this study, GBS data of 6 Hanwoo samples (H1~6) showing differing level of DNA degradation were compared. Re-sequencing pipeline was followed to investigate the impact of DNA degradation on marker discovery. As a result, we found that the quantity and quality of SNPs were not affected in the sample H5 and H6 with moderately degraded DNA. On the other hand, marker discovery was greatly affected in samples with severe DNA degradation (H3 and H4). The findings in this study support that GBS is a robust genotyping method towards moderate DNA degradation.

The present study is aimed at determining how teaching and learning in Japanese translation/interpretation classes are linked to the modality relationships among hearsay markers, which are schematized after dividing the difference of pragmatics in the three following relationships: information and speaker, information and listener, and speaker and listener. Information about seven Japanese hearsay markers was collected through a questionnaire over native Japanese speakers. The findings revealed that people, first, chose [youda] and [toiukotoda] usually as the hearsay expressions, considering the relationship between information and speaker. Second, people divided [tonokotoda] into two relationships between information and speaker, or between information and listener. The responses about [souda] were split considering the relationship between information and speaker and speaker and listener. [Rashi] and [toka] were chosen the most, considering the relationship between information and listener, and there was a relatively large number of [toiu(utte)].

쇠검은머리쑥새(Emberiza yessoensis)는 국내 및 중국, 일 본 등에서 월동하는 겨울철새로, 이들의 번식지는 국내를 제외한 러시아, 몽골, 중국, 일본의 일부지역에 분포하는 것으 로 알려져 왔다. 그러나 최근 국내 번식 사례가 최초로 관찰되 어, 이후 이들 개체군을 보전하기 위한 기초연구 필요성이 대두되었다. 쇠검은머리쑥새는 국제자연보전연맹(IUCN)에 서 준위협(NT)종으로 취급되고 있으며, 국내의 경우 멸종위 기야생생물 II급으로 지정되어있다. 이들의 국내 서식지는 현재까지 지속적으로 감소하고 있어, 월동 및 번식개체군 모두 위협받고 있는 것으로 판단된다. 그럼에도 불구하고 개체군 크기, 서식지 면적 등 이들의 정확한 국내 개체군 기초정보는 현재까지 알려지지 않아 이들의 멸종위기 위험정 도를 객관적으로 파악하는데 어려움이 있다. 우리의 연구목 적은 쇠검은머리쑥새의 국내 멸종위기 등급을 판정하는데 도움을 줄 수 있는 유전정보를 제공하는 것이다. 우리는 이를 위해 10개 이상의 microsatellite 분자표지자를 개발하고 있 다. 현재까지 29개의 분자표지자를 디자인 하였으며, 10개의 다형성을 나타내는 microsatellite 유전자좌를 관찰하였다. 이 중 4개 유전자좌의 유전다양성을 경기 안산지역에 서식중 인 32개체의 쇠검은머리쑥새 번식개체군을 대상으로 분석한 결과, 대립유전자수(A)는 2~16개, 관찰이형접합빈도(HO)와 기대이형접합빈도(HE)는 각각 0.06~0.78, 0.12~0.90의 범위 를 나타냈다. 향후 10개 이상의 microsatellite 분자표지자를 개발하여 쇠검은머리쑥새 번식개체군의 유전다양성 및 유전 구조를 파악 할 것이며, 이를 통해 개체군 기초정보가 알려져 있지 않은 국내 쇠검은머리쑥새 번식개체군 보전방안 수립을 위한 객관적인 기준을 제시할 것이다. 이 연구에서 개발한 microsatellite 분자표지자는 국내뿐만 아니라 국외에 서식중 인 쇠검은머리쑥새 개체군 보전 연구에 유용하게 활용될 것이다.

OBJECTIVES : A fog generated field test was conducted to analyze the relationship between different sizes of variable speed limit signs and the legibility distance under various fog density conditions. By using this study, appropriate sizes of signs can be selected depending on the density of fog. METHODS : An actual tunnel was selected as the area for this test, as other places cannot maintain the fog condition because of rapid air current. A total 121 subjects were recruited for this test, which took place over the course of four days. The test on the first day was conducted under normal weather conditions for comparison. Visibility-distance detecting sensor was used to measure the visibility distance due to the fog density time, simultaneously with the evaluation of legibility distance by subjects. RESULTS : The test results show the relationship between the different sizes of signs and the legibility distance corresponding to the visibility distance due to both non-fog and fog generated conditions. According to the technical test results, appreciable amount of reduction in legibility distance due to fog was resulted in all sizes of signs. Moreover, the legibility distance is reduced proportionately with the decrease in the visibility distance due to fog. CONCLUSIONS : The results of this study can be used to select appropriate sizes of valuable speed signs under fog conditions. Hence, drivers can expect to have more room to respond to adverse weather conditions, thereby reducing the risk of accidents.

OBJECTIVES : A fog generated field test was conducted to analyze the relationship between the luminance of variable speed-limit signs and the legibility distance under various fog density conditions. By using this study, appropriate luminance values can be selected depending on the density of fog. METHODS: An actual tunnel was selected as the area to conduct the test, as other places cannot maintain the fog condition because of rapid air current. Ninety-two subjects were recruited for this test, which took place during the course of three days. Visibility-distance detecting sensor was used to measure the visibility distance due to the fog density time, simultaneously with the evaluation of legibility distance by subjects. RESULTS: The test results show the relationship between luminance values and the legibility distance corresponding to the visibility distance due to fog. According to the technical test results, lower luminance value such as 7000 cd/m2 corresponds to less legibility distance compared to higher values such as 20000 cd/m2 or 40000 cd/m2. However, the amount of difference between 20000 cd/m2 and 40000 cd/m2 is negligible in our test. CONCLUSIONS: The results of this study can be used to select appropriate luminance of valuable speed signs under fog conditions. Hence, drivers can expect to have more room to respond to adverse weather conditions, thereby reducing the risk of accidents.