This paper presents a framework for developing aftershock fragility curves for reinforced concrete bridges initially damaged by mainshocks. The presented aftershock fragility is a damage-dependent fragility function, which is conditioned on an initial damage state resulting from mainshocks. The presented framework can capture the cumulative damage of as-built bridges due to mainshock-aftershock sequences as well as the reduced vulnerability of bridges repaired with CFRP pier jackets. To achieve this goal, the numerical model of column jackets is firstly presented and then validated using existing experimental data available in literature. A four-span concrete boxgirder bridge is selected as a case study to examine the application of the presented framework. The aftershock fragility curves are derived using response data from back-to-back nonlinear dynamic analyses under mainshock-aftershock sequences. The aftershock fragility curves for as-built bridge columns are firstly compared with different levels of initial damage state, and then the post-repair effect of FRP pier jacket is examined through the comparison of aftershock fragility curves for as-built and repaired piers.