최근 건설시장에 4차 산업혁명기술의 급속한 확산과 도입, 적용이 트랜드로 부각되고 있다. BIM 기술은 4차 산업혁명 기술의 근간을 이루는 다차원 정보체계이다. 이러한 정보기반체계를 활용한 하천분야도 유지관리를 위한 현행화 방안 등 적극적인 연구검토가 되고 있다. 최근 하천 전문가들의 하천분야 BIM도입 효과에 필요성을 반영하여 적극적인 연구와 현행화 작업을 해야 된다. 그리고 첨단기술을 반영한 시설물 유지관리 정보체계를 활성화하고 관리계획 수립 및 운영을 위해서는 다양한 정보체계를 구축하기 위한 도구 및 지원소프트웨어의 개발이 반드시 필요할 것으로 전망된다. 하천시설의 유지운영을 위한 연구로 기본적으로 기존 도면자료를 이용하여 3차원 정보모델을 구축하고 이를 활용한 손상을 점검하고 정보화하며 보수보강을 위한 자료로 활용토록 하는 것이다. 이는 기존 도면방식에 없는 정보체계를 하천시설물을 3D 모델링과 함께 유지관리정보를 속성으로 구축하는 방법을 연구하여 유지운영을 위한 점검, 손상 관리를 보다 효과적이고 활용성이 높은 관리방안을 제시하고자 하였다.

흑다리긴노린재 약충 및 성충에 의한 벼 이삭 피해를 다양한 조건에서 분석하였다. 흑다리긴노린재 약충 1마리를 1일간 접종하였을 경우 주당 평균 2.7개, 16마리를 16일간 접종하였을 때 주당 평균 132.3개의 반점미가 발생되었다. 접종밀도와 반점미 발생 입수와는 고도의 정의 상 관관계를 나타내었다(Y = 8.8446X, r2 = 0.9622). 출수기에 흑다리긴노린재 성충 1쌍을 접종한 경우 벼 수확 시 발생한 피해로 동할미율은 40.2%, 반점미율은 30.5%였으며, 16쌍을 처리한 경우 동할미율은 81.7%, 반점미율은 74.5% 발생되었다. 벼의 등숙 정도에 따른 피해 양상을 분석한 결과 출수 초기에 가해하였을 경우에는 벼의 등숙율을 감소시키는 경향을 보였으며, 중기 및 후기에 가해하였을 경우 동할미율과 반점미 율이 증가하는 경향을 나타내어 가해시기에 따라 벼 이삭 피해의 차이가 현저하였다.

본 논문에서는 전산구조 해석 데이터를 기반으로 인공 신경망을 활용하여 헬리데크 구조물에 대한 손상 추정 기법을 제안하였다. 헬리데크를 구성하는 트러스와 서포트 부재들에 대해서 절점을 공유하는 부재들을 70개의 모델로 그룹화 하였으며, 최대 3가지 부재 그룹에 무작위로 손상을 부여하여 총 37,400개의 손상 시나리오를 생성하였다. 이들 각각에 대해서 구조 해석 프로그램을 통해 모드 해석을 수행하였으며, 전체 손상 시나리오를 사용 목적에 따라 학습, 유효성 검사, 그리고 검증 시나리오로 분리하였다. 헬리데크의 손상 및 비손상 상태의 동적 응답 특성에 대한 패턴 인식을 위해 PyTorch 프로그램을 활용하여 3개의 은닉층을 가지는 인공 신경망을 구성하였으며, 이에 대해서 다양한 손상 시나리오를 반복 학습함으로써 손실 함수를 최소로 하는 인공 신경망을 도출하였다. 최종적으로 총 400개의 검증 시나리오에 대해서 인공 신경망이 추정한 손상률과 실제 부여된 손상률을 비교하였으며, 그 결과 본 연구를 통해 얻어진 인공 신경망이 손상 부재의 위치와 손상 정도를 매우 높은 정확도로 예측하는 것을 확인하였다.

Generally the non-bearing walls in apartment buildings in Korea are not considered as a lateral force resisting members for the design consideration. This engineering practice caused large crack damages and brittle fractures of the non-bearing walls when subjected to Pohang earthquakes in 2017 since those have not been designed for seismic loading. In this study, finite element analysis was conducted for slot type non-bearing wall connection system to reduce damages and concentrate damages to the designated damping device through separation from the structural wall members. Steel plate and dowel bar systems designed for the dissipation of seismic energies were modeled and analyzed to investigate the damage reductions. Finally, the test result and the analysis result were compared and verified.

Baicalin is a flavonoid compound with many advantages, including anti-inflammatory agents and antioxidants. Lipopolysaccharide (LPS) is an endotoxin that induces neuronal damage through inflammatory response and oxidative stress reaction. This study was investigated the protective effects of baicalin on the oxidative stress and histopathological changes caused by LPS in hippocampus. Adult mice were divided into four groups; vehicle-treated, baicalin-treated, LPS-treated, and LPS and baicalin co-treated animals. Baicalin (10 mg/kg/day) and/or LPS (250 μg/kg/day) were intraperitoneally administered for seven consecutive days, and body weight was measured. Reactive oxygen species (ROS) level and lipid peroxidation level in the hippocampus were examined. Histopathological study was performed using hematoxylin and eosin staining manuals. LPS treatment decreased body weight and increased ROS and oxidative stress in the hippocampus. However, co-treatment with baicalin alleviated these changes caused by LPS. Severe histopathological changes were observed in the hippocampus of LPS-treated animals. Baicalin co-treatment attenuated the changes and preserved neuronal cells from LPS damage. These results showed that baicalin suppresses LPS-induced neuronal damage by alleviating oxidative stress in the hippocampus. Thus, this study demonstrated that baicalin exerts protective effects against LPS-induced oxidative stress in hippocampus.

Earthquake preparedness has become more important with recent increase in the number of earthquakes in Korea, but many existing structures are not prepared for earthquakes. There are various types of liquefaction prevention method that can be applied, such as compaction, replacement, dewatering, and inhibition of shear strain. However, most of the liquefaction prevention methods are applied before construction, and it is important to find optimal methods that can be applied to existing structures and that have few effects on the environment, such as noise, vibration, and changes in underground water level. The purpose of this study is to estimate the correlation between the displacement of a structure and variations of pore water pressure on the ground in accordance with the depth of the sheet file when liquidation occurs. To achieve this, a shaking table test was performed for Joo-Mun-Jin standard sand and an earth pressure, accelerometer, pore water pressure transducer, and LVDT were installed in both the non-liquefiable layer and the liquefiable layer to measure the subsidence and excess pore water pressure in accordance with the time of each embedded depth. Then the results were analyzed. A comparison of the pore water pressure in accordance with Hsp/Hsl was shown to prevent lateral water flow at 1, 0.85 and confirmed that the pore water pressure increased. In addition, the relationship between Hsp/Hsl and subsidence was expressed as a trend line to calculate the expected settlement rate formula for the embedded depth ratio.

The feedwater heaters are critical components in a nuclear power plant. As the operation years of heaters go by, the maintenance costs required for continuous operation increase. Integral drains cooler is the separate heat exchanger combined in the heater shell. The integral drains cooler must be isolated from the other zones. The integral drains cooler must be free from leakage and the entrance into the zone be sealed against the entrance of steam from the condensing zone. Cause of tubes leakage since tubes replacement is the same as the cause before tubes replacement. Therefore, feedwater refurbishment method was selected by heater internal structure condition.

초음파 탐상은 다양한 콘크리트 구조물의 비파괴검사에서 활용된다. 본 연구에서는 골재형상을 고려한 골재-모르타르 모델 생성과 초음파 전파 해석을 수행하였다. 실제 골재형상을 반영하기 위해 이미지처리를 통한 골재-모르타르 단면으로부터 모르타르와 골재 영역을 파악하고, 영역 경계형상을 보존하면서 격자를 생성하는 기법을 개발하였다. 개발된 기법에서는 모든 격자가 4각형으로 생성된다. 골재-모르타르 모델을 통해 초음파 전파 해석을 수행하였고 모델을 반무한체로 간주하기 위해 CALM 기반 경계흡수 조건을 적용하였다. 골재 및 결함을 포함한 이미지로부터 격자를 생성한 뒤, 결함 영역에 포함된 격자를 제거하여 공극결함을 모사하였다. 본격적인 결함탐지 전 선행 해석을 통해 모델 동특성을 고려한 적절한 가진 주파수를 결정 및 가진 신호형상을 설계하였다. 이후 case 별 초음파 전파 해석을 통해 신호를 획득하고 신호 에너지 맵핑 작업을 통해 내부 결함을 가시화 하였다. 가시화 결과, 골재에 의한 다수 반사 및 산란현상이 관찰되지만 결함부에서 신호 에너지는 가장 높게 나타났으며 모든 해석 case에서 결함위치 추정이 가능하였다. 또한 균열의 경우 형상파악도 가능하였다.

자연재해 발생을 예방하기 위한 방재센서 기술이 중요하며 광섬유를 이용한 센서에 대한 관심이 높아지고 있다. 본 논문은 광섬유 센서 내장 탄소섬유시트로 보강된 RC보의 계측된 데이터로 결함 탐지 연구를 수행하였다. 미분의 국부적 변동 특성을 이용한 Method Ⅰ과 컨벌루션 방법을 이용한 Method Ⅱ를 비교, 분석하였다. 다른 차원의 데이터를 비교하기 위해서 무차원화 시켰으며, 분석 결과 Mehtod Ⅱ가 결함의 위치를 예리하게 잘 탐지하는 것으로 나타났다. Method Ⅱ인 컨벌루션에 사용 되는 필터 벡터를 잘 응용하면 더 좋은 효과를 기대할 수 있을 것으로 판단된다.

Big data analysis methods are useful tools for sorting valuable data and products. Achyranthes Radix root extract (AR) is a well-known herbal medicine in East Asia due to its anti-osteoarthritis, pro-circulatory, and anti-osteoporosis effects. In this stud y, we investigated the liver- and kidney-protective effects of AR by applying big data analysis to traditional medicine. CDDP (cis-diamminedichloridoplatinum) is an effective cancer cell anti-proliferative agent used in the treatment of diverse types of tumors. However, it is clinically limited due to liver and kidney toxicity. The current study was designed to assess the potential protective effects of AR against CDDP-induced hepato-renal toxicity. For this purpose, male Sprague-Dawley (SD) rats were assigned to four groups, each consisting of four animals. Intravenous injection or oral administration of either saline or AR was performed daily for 14 days, whereas CDDP was injected intraperitoneally on day 3 following AR treatment. Serum biochemistry results revealed that CDDP induced clear hepatic and renal damage while the AR treatment groups showed less damage relative to controls. Next, we tested the pharmacokinetics of AR using 20-hydroxyecdysone (20-HE), which is the most abundant component of AR extract. After intravenous administration of AR, the plasma concentration of 20-HE rapidly declined with a terminal half-life (t1/2) of 0.99±0.47 h. The area under the plasma concentration vs. time curve was 24.96±3.5 h*ng/mL. The present study provides valuable tools for further verification studies of the classical herbal literature and its scientific relevance.

본 연구에서는 LNG 추진선에서 배관의 파손으로 천연가스가 누출되었을 때 누출공의 크기별 플래시 화재, 과압, 복사열에 따 른 피해범위를 ALOHA(Areal Location of Hazardous Atmospheres)를 이용하여 산출했다. 그리고 민감도 분석을 위해 환경 변수(풍속, 대기온 도, 대기 안정도)와 공정 변수(배관 압력, 배관 길이)로 구분하여 다양한 시나리오별 피해영향범위를 분석했다. 그 결과 환경 변수에 따른 피해범위는 플래시 화재에 의한 피해범위가 가장 컸으며 다음으로 과압, 복사열 순서로 큰 피해범위를 나타냈다. 그리고 공정 변수에 따른 피해범위를 산출한 결과 배관의 압력과 길이, 누출공의 크기와 관계없이 플래시 화재에 의한 피해범위가 가장 컸으며, 환경 변수와 동일하게 과압, 복사열 순서로 높은 피해범위를 보였다. 또한 누출공의 크기가 클수록 환경 변수와 공정 변수가 피해범위에 큰 영향을 주었으며 제트 환재에 의한 피해범위는 환경 변수에 비해 공정 변수에 의한 피해범위가 더 큰 것을 알 수 있었다.

In this study, we investigated the protective effects of Ulva lactuca methanol extracts against ultraviolet B (UVB)-induced DNA damage in HaCaT cells. First, the contents of general and antioxidative nutrient contents of Ulva lactuca were measured. The moisture, carbohydrate, crude protein, crude fat and ash were 14.01%, 44.80%, 23.19%, 3.10% and 14.90%, respectively. Magnesium that acts as DNA repair enzyme cofactor was the most abundant mineral followed by Ca, P and Fe. The total phenolic and anthocyanoside contents of Ulva lactuca were 2.69 mg/g and 0.13 mg/g, respectively. Cells treated with Ulva lactuca methanol extracts for 24 hours post UVB exposure increased cell viability in a concentration-dependent manner compared to the non-treated control. Also, Ulva lactuca methanol extracts decreased the levels of UVB-induced DNA damage such as cyclobutane pyrimidine dimer and DNA damage response (DDR) proteins such as p-p53 and p21. These results suggest that Ulva lactuca methanol extracts comprising physiological active substances such as Mg, polyphenols and anthocyanosides promote DNA repair by regulating genes related with DDR.

Phaya-Thon-Zu temple has a unique architectural style connected by the three temples, and cultural values are highly as murals remain on some of the walls. However, various damages in internal walls and vaults have occurred due to earthquake and environmental influences. In order to analyze these damages, accurate structural analysis is required, but structural modeling is difficult, because Phaya-Thon-Zu temple is the complex masonry structure which is stacked with small bricks. Therefore, this study intends to analyze the causes of damages by examining collapse mechanism for cross section and longitudinal section of vaults in the entrance hall and shrine by using thrust line analysis, which is a geometric method, and to compare it with the actual damage situation.

The purpose of this study was to examine the characteristics of acetaminophen (APAP)-induced liver damage, using fluorescence bioimaging, serum biochemistry, and histopathology. At six weeks of age, eighteen mice were divided into three groups as group 1 (G1) as control, group 2 (G2) as fluorescence probe control and group 3 (G3) as APAP-treated. G3 mice were orally treated with APAP (800 mg/kg b.w.), while G1 and G2 mice were treated with 0.9% saline. Twenty-two hours after APAP treatment, G2 and G3 mice were intravenously treated with Annexin-Vivo 750 as probe, while G1 mice were treated with saline. Fluorescence bioimaging was performed at two hours after probe treatment. The mice were sacrificed and serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and lactate dehydrogenase were analyzed. Liver damage was examined by hematoxylin and eosin (H&E) staining and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining. In vivo bioimaging, fluorescence intensity of the region of interest (ROI) was significantly increased in the livers of G2 and G3 mice compared with those in G1 mice (p<0.05 and p<0.01). In addition, ex vivo bioimaging confirmed that the fluorescence intensity of the ROI was significantly increased in the livers of G2 and G3 mice compared with those in G1 mice (p<0.05 and p<0.01). All examined serum parameters of G3 were significantly increased compared with G1 and G2 (p<0.05 and p<0.01). H&E examination showed acute hepatic cell necrosis in the livers of G3 mice, while there was no cell death in the livers of G1 and G2 mice. TUNEL staining also showed many cell death features in G3 mice, whereas no pathological findings were shown in G1 or G2 mice. In summary, fluorescence bioimaging showed the possibility of cell death detection in the livers of mice treated with APAP, and this was corroborated by serum chemistry and histopathological examination.