Small modular reactors (SMRs) are getting attention as an alternative to fossil fuel power stations due to versatile application and carbon dioxide reduction. Although various types of advanced reactors are being developed, water-cooled SMR will be first deployed on a commercial scale. The International Atomic Energy Agency (IAEA) and regulatory bodies are trying to identify safeguards issues of water-cooled SMRs as the first priority. IAEA begins to develop a safeguards plan by asking for the facility’s specification in a given format, a design information questionnaire (DIQ). Then, IAEA periodically performs safeguards activities such as design information verification (DIV) and physical inventory verification (PIV). In this sense, we utilize research and power reactor DIQ for water-cooled SMRs (NuScale, SMART, i-SMR and KLT-40S). Most of the questions are answered with open information. For undisclosed answers, pressurized water reactor (PWR) features are described. Safeguards issues in water-cooled SMR originate from core modularization. As the nuclear material flows are diversified, the number of safeguards measure will be increased while staff are reduced in SMRs. Instrumentation for safeguards should be developed to reduce worker’s fatigue level. Intensive arrangement of fuel assemblies may also need unique devices to secure their visibility or detectability. A transparent floor with a surveillance system or advanced Cherenkov viewing device may be adopted to enhance containment and surveillance. Meanwhile, some questions could be more elaborate regarding safeguards. First, question #38 cannot confirm the time of occurrence of weapon-grade plutonium for reactor operation. Second, the answers in questions #46 and #49 are primitive to identify a place to generate an undeclared fissile material. Therefore, the current DIQ should be revised to get a detailed burnup report and spatial distribution of neutron flux.