본 연구는 코로나바이러스 감염증-19(이하 코로나19) 팬데믹 상황에서 간호대학생의 취업불안 에 코로나19에 대한 지식과 두려움이 어떠한 영향을 주는지 확인하기 위해 시도되었다. 본 연구대상자는 간호대학에 재학 중인 1학년에서 4학년까지 157명이었으며, 자료수집은 2021년 12월 9일부터 2022년 2월 21일까지 연구에 동의한 간호대학생을 대상으로 시행하였다. 수집된 자료의 일반적 특성에 따른 취업불안 정도의 차이는 Independent t-test, One-way ANOVA로 분석하였고, 변수 간의 상관관계는 Pearson correlation coefficient로, 간호대학생의 취업불안에 영향을 미치는 요인은 단계적 다중회귀 방법을 사용하 여 통계적으로 분석하였다. 본 연구결과, 연구대상자들의 취업불안은 코로나19에 대한 두려움(r=.386, p<.001)과 유의한 상관관계가 있었으며, 간호대학생의 취업불안을 예측할 수 있는 주요한 요인은 코로나19 에 대한 두려움과 대학 생활 만족도였다. 이상의 결과를 볼 때 코로나19에 의한 간호대학생의 취업불안을 줄이기 위해서 취업을 준비하는 학생들에게 두려움을 줄이고 긍정적 정서를 향상할 수 있는 다양한 프로그 램을 마련할 필요가 있다.

Tet1 is well known initiatior of DNA demethylation by converting 5-methylcytosine to 5-hydroxymethylcytosine in CpG-rich regions of the brain. There have been studies using Tet1-KO mice about adult neurogenesis, cognition and memory extinction, it is still unclear whether Tet1 overexpression is beneficial for CNS networks. Thus in this study, Tet1 overexpression TG mice were developed and behavioral phenotypes were analyzed with related gene studies. Most of all, they showed anxiety-like behaviors and improved memories with increased immature neurons in the hippocampal dentate gyrus. Hence, they showed increased immediate-early gene levels (c-Fos, Arc, Egr-1, and BDNF), activation of intracellular calcium signaling (CamKII, ERK, and CREB) and changes in the expression of GABA receptor subunits (GABRA2, and GABRA4) in several brain regions. By overexpressing Tet1 in NB41A3 cells, effect of Tet1 overexpression on intracellular calcium levels with higher Egr-1 promoter activity was evaluated. These findings suggests Tet1 overexpression affects excitatory synaptic networks via activating NMDAR-dependent calcium signaling which leads to dysregulation of inhibitory synaptic networks. Also, it implies chronic and excessive activation of intraneuronal calcium signaling by Tet1 leads to behavioral differences in mice. Additionally, it suggests Tet1 overexpression in the PFC, hippocampus, and amygdala contributes as both beneficial and harmful for neural networks in differing aspects.

This study highlights empirically the relationship among major constructs such as accident, fear and anxiety emotion, self-efficacy, and negative spillover of work, focused on the railway drivers. The differentiated factor of this study is in that the experience of accident was posed as exogenous variable. Hypothesis tests based on 201 samples verified that the experience of accidents showed a significant effect on negative spillover of work mediated by fear and anxiety, with moderating effect of self-efficacy between fear and anxiety and negative spillover of work. However, the moderating effect was shown as increasing the degree of negative spillover of work, since the drivers recognized their fear and anxiety accrued by accident experience as uncontrollable. This finding suggests the need for mitigating driver's negative emotion - fear and anxiety - through an introduction of practice such as exemption of settlement obligation in accident site and lowering of the penalty for accident responsibility.

This study highlights empirically the relationship among major constructs such as accident, fear and anxiety emotion, self-efficacy, and negative spillover of work, focused on the railway drivers. The differentiated factor of this study is in that the experience of accident was posed as exogenous variable. The main statistical tool was Regression. Hypothesis tests based on 201 samples verified that the experience of accidents showed a significant effect on negative spillover of work mediated by fear and anxiety, with moderating effect of self-efficacy between fear and anxiety and negative spillover of work. However, the moderating effect was shown as increasing the degree of negative spillover of work, since the drivers recognized their fear and anxiety accrued by accident experience as uncontrollable. This findings suggest the need for mitigating driver's negative emotion - fear and anxiety - through an introduction of practice such as exemption of settlement obligation in accident site and lowering of the penalty for accident responsibility.