We first deduce a uniform formula forthe Fermi energy of degenerate and relativistic electrons in the weak-magnetic field approximation. Then we obtain an expression of the special solution for the electron Fermi energy through this formula, and express the electron Fermi energy as a function of electron fraction and matter density. Our method is universally suitable for relativistic electron- matter regions in neutron stars in the weak-magnetic field approximation.

The present study is undertaken to evaluate the effect of volume fraction on the results of Charpy impact test for the rubber matrix filled with nano sized silica particles composites. The Charpy impact tests are conducted in the temperature range 0°C and –10°C. The range of volume fraction of silica particles tested are between 11% to 25%. The critical energy release rate GIC of the rubber matrix composites filled with nano sized silica particles is affected by silica volume fraction and it is shown that the value of GIC decreases as volume fraction increases. In regions close to the initial crack tip, fracture processes such as matrix deformation, silica particle debonding and delamination, and/or pull out between particles and matrix which is ascertained by SEM photographs of Charpy impact fracture surfaces.

양파 과육과 과피의 생리학적 효과를 평가하기 위하여, in vitro 항산화 활성과 H2O2로 유도된 산화적 스트레스에 대한 PC12 세포보호 효과를 확인하였다. 그 결과, 양파의 과육과 과피 모두 EtOAc 분획물에서 가장 높은 ABTS, DPPH 라디칼 소거활성과 MDA 저해활성을 나타냈다. 양파의 과육과 과피의 EtOAc 분획물을 이용하여, H2O2로 산화적 스트레스를 유발한 PC12세포에서의 ROS 함량과 세포보호효과를 DCF-DA assay, MTT assay 및 LDH assay를 통하여 확인한 결과, 과피가 과육 대비 약 10배 낮은 농도에서 비슷한 보호효과를 나타내었다. 최종적으로 GC-MS를 이용하여 주요 페놀성 화합물인 quercetin 함량과 quercetin 배당체 함량을 분석한 결과, 양파 과육(각각, 4.83, 8.70mg/100g dry weight)과 과피(91.80, 61.81mg/100g dry weight, respectively) 함량을 나타내었다. 이러한 결과들을 종합해볼 때, 양파 과피뿐만 아니라 과육이 나타내는 항산화 효과 및 산화적 스트레스에 대한 신경세포 보호효과는 퇴행성 신경질환과 같은 질병에서 효과적인 소재일 것이라고 사료된다.

In recent years, industrial demands for superior mechanical properties of powder metallurgy steel components with low cost are rapidly growing. Sinter hardening that combines sintering and heat treatment in continuous one step is cost-effective. The cooling rate during the sinter hardening process dominates material microstructures, which finally determine the mechanical properties of the parts. This research establishes a numerical model of the relation between various cooling rates and microstructures in a sinter hardenable material. The evolution of a martensitic phase in the treated microstructure during end quench tests using various cooling media of water, oil, and air is predicted from the cooling rate, which is influenced by cooling conditions, using the finite element method simulations. The effects of the cooling condition on the microstructure of the sinter hardening material are found. The obtained limiting size of the sinter hardening part is helpful to design complicate shaped components.

This study was designed to determine the antioxidant activity of solvent fractions of broccoli sprouts grown by controlling the growing environment at the plant factory system. Fractionation was achieved with chloroform, n-hexane, ethyl acetate, butanol, water by 70% EtOH extract of the broccoli sprouts. Each solvent fraction was put through TLC and HPLC to separate active components. Higher antioxidant activities were observed for the butanol and ethyl acetate layers. Further evaluation of each of the 5 layers (LH1 to LH5) of the butanol fraction showed that the refined LH3 extract had a high antioxidant effect. Components with similar Rf values from TLC had the same retention times and peaks in the HPLC analysis. It was also determined that the sulforaphane content was high at the chloroform and butanol layers and the sulforaphane was responsible for, the high antioxidant activity. Thus, to use for functional materials, the butanol extract/layer of broccoli sprouts is recommended as the most effective.

목 적 : Multi echo Dixon을 기반으로 한 PDFF(Proton Density Fat Fraction) 기법을 이용하여 넓은 간 영역의 지방 함량을 계산하고 자기공명분광법(MRS)과 비교 분석하여 불균질 적으로 침착된 지방간에서의 유용성을 입증함에 목적을 두고 있다. 대상 및 방법 : 2013년 2월부터 7월까지 본원에서 복부 자기공명 영상검사를 시행한 환자 142명(남: 97, 여: 45, 평균연령: 57.9세)을 대상으로 분석하였다. MR System은 3.0T Magnetom Tim Verio(Siemens Healthcare, Germany)를 사용하여 Multi echo Dixon(3D VIBE DIXON), MRS(Single voxel high speed T2 corrected multiple echo 1H-MR spectroscopy) 기법을 시행하였다. Multi echo Dixon의 영상변수는 TR은 9.2msec이고 TE는 1.23, 2.46, 3.69, 4.92, 6.15, 7.38msec이며 Slice thickness는 4mm, Matrix: 165×256, FOV: 315×420이며, MRS에서 TR은 3,000msec 이고 TE는 12, 24, 36, 48, 72msec, Voxel size: 30×30×30mm를 사용하여 각각의 영상을 획득하였다. 획득한 PDFF Fat percentage map 상의 각각의 7개의 엽에 (II-VIII) ROI를 설정하였으며(“Segmental-PDFF”), MRS의 VOI와 같은 지점에 ROI를 설정하였다(“VOI-PDFF”). 그리고 서로 다른 세 지점에 Tablet pen을 이용하여 Liver margin을 따라 ROI를 그렸다(“Free drawn-PDFF”). 지방분율 cut-off 값인 5.56%를 기준으로 T-test, Pearson’s correlation, Linear regression test, McNemar test를 이용하여 PDFF와 MRS의 상관관계 및 좌, 우엽의 지방 함유 관계와 각각의 진단적 능력에 대해 비교 분석하였다. 결 과 : Mean fat percentage는 Free-drawn PDFF(4.5%±3.7)와 VOI-PDFF(4.5%±4.1)가 MRS(4.5%±4.3)에 가장 근접한 결과 값을 보였고, 그 중 VOI-PDFF가 가장 높은 일치성을 보였다(r=0.972, r2=0.944). 또한 지방증과 비 지방증 집단에서 우엽이 좌엽보다 더 높은 지방 함유를 나타냈다(7:2). 또한 MRS는 142명 중 40명(28%)을 지방증으로 구분하였고, Free-drawn PDFF는 32명(22.5%)을 지방증으로 구분하였다. 결 론 : MRS에서는 VOI를 국소적인 곳에 위치시켜야 하기 때문에 넓은 영역에 불균질하게 분포 되어 있는 지방을 정량화함에 있어 지방분율 Cut-off 값인 5.56%를 기준으로 지방증을 진단하는데 다소 부정확 할 수 있음을 시사한다. 반면 PDFF의 Free-drawn 기법은 간 전체 영역의 지방을 정량화함으로 이러한 문제점을 보완 할 수 있다. 따라서 Reference standard로서 MRS기법을 대체 할 수 있을 것으로 사료 된다.

Anthocyanins, a class of flavonoids, are natural water-soluble pigments, which are mainly found in vegetables and fruits. Anthocyanins have attractive pharmacological activities, such as anti-oxidant, anti-inflammatory, anti-cancer, and anti-diabetic. The purpose of this study was to investigate the protective effects of anthocyanins-rich fraction (ANF) from Korean purple sweet potato variety, "Shinjami", against hydrogen peroxide (H2O2)-induced oxidative stress. In our results, pre-treatment of HepG2 cells with ANF (10μg/mL) significantly prevented cell death and maintained cell integrity, following exposure to 0.9 mM hydrogen peroxide. The H2O2-dependent production of intracellular ROS was also significantly decreased by pre-treatment with ANF (6 h, 10μg/mL). In addition, ANF increased the mRNA levels of antioxidant enzymes, catalase and glutathione level in H2O2-treated HepG2 cells. These results indicated that ANF protected HepG2 cells against H2O2-induced oxidative stress by inducing protective system.

The inhibitory activities of the Cordyceps pruinosa butanol fraction (Cp-BF) were investigated by determining inflammatory responses of lipopolysaccharide (LPS)-treated RAW264.7 macrophage cells and by evaluating HCl/ethanol (EtOH)-triggered gastric ulcers in mice. The molecular mechanisms of the inhibitory effects of Cp-BF were investigated by identifying target enzymes using biochemical and molecular biological approaches. Cp-BF strongly inhibited the production of NO and TNF-α, release of reactive oxygen species (ROS), phagocytic uptake of FITC-dextran, and mRNA expression levels of interleukin (IL)-6, inducible NO synthase (iNOS), and tumour necrosis factor-alpha (TNF)-α in activated RAW264.7 cells. Cp-BF also strongly down regulated the NF-κB pathway by suppressing IKKβ according to luciferase reporter assays and immunoblot analysis. Furthermore, Cp-BF blocked both increased levels of NF-κB-mediated luciferase activities and phosphorylation of p65/p50 observed by IKKβ overexpression. Finally, orally administered Cp-BF was found to attenuate gastric ulcer and block the phosphorylation of IκBα induced by HCl/EtOH. Therefore, these results suggest that the anti-inflammatory activity of Cp-BF may be mediated by suppression of IKKα and its downstream NF-κB activation. Since our group has established the mass cultivation conditions by developing culture conditions for Cordyceps pruinosa, the information presented in this study may be useful for developing new anti-inflammatory agents.

지난 몇 십년동안 전 세계적으로 제조기술 분야의 급속한 성장으로 대부분의 제조 업에서 눈부실만한 품질향상과 생산성 극대화를 이루어 왔다. 하지만 현재 제조기술 분야는 새로운 문제에 직면하고 있다. 실제 현장에서 관리하고자하는 품질특성은 정규 분포를 따르지 않는 경우가 많은데, 대부분의 통계적 공정관리기술체계가 정규분포를 기반으로 하고 있다는 것이다. 이러한 이유로 비정규 공정에서 극소불량관리, 미세변 동관리에 대한 연구가 시급한 실정이다. 본 논문에서는 비정규 공정에서 불량률을 관리하기 위해 다양한 비정규 분포를 대 표할 수 있는 Burr 분포를 선택하여 적용방법을 제안하고자 한다.

Physalis alkekengi var. francheti Hort. is known as an insecticide and traditional remedy for liver related diseases. Therefore, this study investigated the chemopreventive effects of extracts and several solvent fractions (n-hexane, dichloromethane, n-butanol, water) of Physalis alkekengi var. francheti Hort. First, their cytotoxicity and NQO1 activity were measured using an MTT assay, plus a quinone reductase [NAD(P)H dehydrogenase (quinone); NAD(P)H: (quinone acceptor) oxidoreductase, EC 1.6.99.2]-inducing activity assay was performed using cultured murine hepatoma cells (Hepa1c1c7) and its mutant cells(BpRc1). The reduction of electrophilic quinones by NQO1 is an important detoxification pathway and major mechanism of chemoprevention. When compared with the other solvent soluble fractions with different polarities, the dichloromethane fraction of Physalis alkekengi var. francheti Hort. showed a higher NQO1-inducing activity that was also dose-dependent. Moreover, the dichloromethane fraction of Physalis alkekengi var. francheti Hort. induced ARE-luciferase activities in HepG2-C8 cells that were generated by transfecting the ARE-luciferase gene construct, suggesting the Nrf2-ARE-mediated induction of anti-oxidative enzymes. In conclusion, the dichloromethane-soluble fraction of Physalis alkekengi var. francheti Hort. showed a relatively strong induction of detoxifying enzymes, thereby meriting further study to identify the active components and evaluate their potential as cancer preventive agents.

지난 몇 십년동안 전 세계적으로 제조기술 분야의 급속한 성장으로 대부분의 제조 업에서 눈부실만한 품질향상과 생산성 극대화를 이루어 왔다. 하지만 현재 제조기술 분야는 새로운 문제에 직면하고 있다. 실제 현장에서 관리하고자하는 품질특성은 정규 분포를 따르지 않는 경우가 많은데, 대부분의 통계적 공정관리기술체계가 정규분포를 기반으로 하고 있다는 것이다. 이러한 이유로 비정규 공정에서 극소불량관리, 미세변 동관리에 대한 연구가 시급한 실정이다. 본 논문에서는 비정규 공정에서 불량률을 관리하기 위해 누적합 관리도와 다양한 비정규 분포를 대표할 수 있는 Burr 분포를 선택하여 적용방법을 모색한다.

해수와 담수가 공존하는 시화호 상류 기수역에서 입자성유기물에 대한 조류의 영향을 평가하기 위하여, 2005년과 2006년 3월부터 11월까지 기수역내 7개 지점을 대상으로 입자성유기탄소 (particulate organic carbon; POC), 식물플랑크톤 색소(chlorophyll a; Chl-a), pheophytin a; Pheo-a)의 시공간적 변동과 상관관계를 분석하였다. 조사기간 동안 POC 농도는 1.0~76.6 mg L-1 (평균 7.4 mg L-1)의 범위로 봄에 높은 계절변화를 보였으며, 염분성층이 강하고 고탁도층이 형성되는 중류부에서 높은 값을 보였다. 살아있는 식물플랑크톤의 현존량의 지표로 이용되는 Chl-a 농도는 1.3~942.9 μg L-1 (평균 71.0 μg L-1) 범위로 매우 높은 값을 보였고, 4월에 중류부에 최고치를 보여 POC와 유사한 변동을 보였다. 한편 Pheo-a 농도는 1.4~1,545.5 μg L-1 (평균 59.9μg L-1)의 범위로, total Chl-a의 평균 44.2%로 죽거나 활성을 잃은 식물플랑크톤의 양이 많은 것으로 나타났다. POC 농도는 식물플랑크톤 색소와 강한 양의 상관(Chla (r=0.93), total Chl-a (r=0.88), ¤Pheo-a (r=0.81))을 보였는데, 이는 시화호 기수역에서 식물플랑크톤이 POC의 중요한 기원임을 시사한다. 한편 식물플랑크톤 색소와 POC와의 회귀식으로부터 POC/Chl-a 비(82.9)보다 POC/total Chl-a 비(35.9)가 하구에서 조사된 POC/Chla 비(40~60)에 더 유사한 것으로 나타났다. 그러므로 시화호 기수역과 같이 Pheo-a 농도가 높은 수역에서는 조류기원성 POC를 산정하거나 또는 수체의 POC 농도에 대한 식물플랑크톤의 기여도를 평가할 때 Chl-a 농도와 함께 Pheo-a 농도도 함께 고려할 필요가 있다.

The characteristics of abrasive wear of the rubber matrix composites filled with nano sized silica particles were investigated at ambient temperature by pin-on-disc friction test. The range of volume fraction of silica particles tested are between 11% to 25%. The cumulative wear volume and friction coefficient of these materials on particle volume fraction were determined experimentally. The major failure mechanisms were lapping layers, deformation of matrix, ploughing, deboding of particles and microcracking by scanning electric microscopy photograph of the tested surface. The cumulative wear volume showed a tendency to increase nonlinear with increase of sliding distance. As increasing the silica particles of these composites indicated higher friction coefficient.

Two fractions (permeate and retentate) from fiber free Aloe vera gel were prepared using an ultra-filtration (UF) system with a tubular ceramic membrane (MWCO of 50 kDa), and their dilute solution properties were investigated. The intrinsic viscosities of fiber free Aloe vera gel and the retentate and permeate fractions that were prepared by ultra-filtration were 18.48, 37.74, and 2.01 dL/g, respectively. UF aloe retentate as a polysaccharide rich fraction exhibited polyelectrolyte behavior showing a sharp decrease of intrinsic viscosity by the addition of NaCl. However, as its NaCl concentration increasing to 1 M, its intrinsic viscosity slightly increased due to conformational change caused by the high concentration of NaCl. On the one hand, the intrinsic viscosities of the dilute UF-retentate solution were exponentially decreased with increasing temperature, and the temperature dependency of its intrinsic viscosity showed a sharp discontinuity at 30oC instead of a linear Arrhenius behaviour, indicating a variation of flow mechanism or network rearrangement of a molecular chain. The chain stiffness of polysaccharide rich fraction at bellow and above 0.5 M of NaCl addition was 0.048 and 0.515, respectively, showing different stiffenings and significant conformational change. The coil overlap parameter and critical concentration of UF-retentate were 3.0 and 0.08 g/dL, respectively.

Two fractions (permeate and retentate) from fiber-free Aloe vera gel were separated using ultra-filtration (UF) system with tubular ceramic membrane (MWCO of 50 kDa), and their molecular properties were investigated. The retentate of UF Aloe gel was a polysaccharide-rich fraction containing about 2.3-fold higher polysaccharide content than fiber-free gel. The FT-IR and 1H NMR spectra of this fraction showed the characteristic patterns of β-binding polysaccharide and a higher degree of acetylation indicating a higher level of bioactive polysaccharide content. The molecular weight and polydispersity of polysaccharide fraction from GPC (gel permeation chromatography) were determined to be 36.8-43.9 kDa and 1.24, respectively, indicating a kind of undispersed polysaccharide. From the SEM observation, the surface structure of polysaccharide fraction had a gel cluster-like structure with a convoluted rough surface. The molecular conformation by Congo red assay exhibited a property of helix structure confirming the existence of a higher-ordered structure as a biological activity conformation.

PURPOSES : The purpose of the study was to examine dynamic features of concrete after mixing a little macro fiber with small aspect ratio and long length utilized for bridge, tunnel and shotcrete for tensile performance and crack control in domestic/overseas countries with cement concrete pavement mix. METHODS : Coarse aggregates with small aspect ratio and macro fibers with maximum length of approximately 32 mm are introduced in small quantities in the mix proportions of concrete pavement so as to prevent loss of the workability. Then, this study intends to evaluate the applicability of macro fibers in the mix proportions of concrete pavement by examining the basic construction performance, as well as the change of toughness, the equivalent bending strength and the flexural toughness index caused by compression, bending, tension and the flexural stress-displacement curve. RESULTS : As the results, in each kind of macro fiber, polyvinyl alcohol fiber and steel fiber displayed a good performance. CONCLUSIONS : In 0.2 and 0.3% of fiber contents, it is appeared that polyvinyl alcohol fiber has a large effect on improvement of tensile performance and steel fiber on improvement of deforming performance of bending stress.