Owing to the increase in saturation rate of the spent fuel storage pond in the Kori nuclear power plant, the interim spent fuel dry storage facility is scheduled to be constructed at the Kori site. To implement safeguards in the new dry storage facility effectively, the concept of “Safeguards-by- Design” (SBD) should be applied to reflect nuclear safeguard provisions in the earliest design stages. Detailed design information pertaining to dry storage facilities has not been determined; however, the design information related to safeguards have been inferred using case studies and interviews with nuclear power plant operators worldwide. On the basis of the results of the case studies on spent fuel dry storage facilities for light water reactors, most countries apply the metal cask method in containment buildings considering safety. Furthermore, Korean operators are also considering the same method owing to tight licensing schedules and safety issues. Using the Facility Safeguardability Assessment (FSA) methodology (one of the safeguard evaluation methodologies), the difference in design between the heavy water reactor spent fuel dry storage facility, an established IAEA safeguards approach reference nuclear facility, and the light water reactor spent fuel dry storage facility (the new nuclear facility) were analyzed. Two major differences were noted as issues pertaining to potential safeguards. First, the difference in design and transport method in terms of the difference in size and weight of the spent nuclear fuel is important; light water reactor fuel is 20 times heavier than heavy water reactor that needs partial defect inspection in assemblies. Second, the difference in safeguard approach owing to the difference between the modular storage method in heavy water reactor and the container type storage method in light water reactor must be considered; movable storage cask renders the IAEA surveillance approach difficult. The results of this study can be used to identify the safeguards requirements in advance, enabling the operator to design new dry storage facilities resulting in timely and cost-effective implementation.