「Seqalu: Formosa 1867」, a movie based on Yaochang Chen (陳耀昌)’s historic novel 「Lady the Butterfly」, aired on Taiwan’s public broadcaster in August of 2021 and obtained the highest viewership. Furthermore, Yaochang Chen’s novel series 福爾摩沙三族記, 獅頭花, 苦楝花, and 島之曦 were reprinted, which all became best sellers, creating a big wave of of rediscovering Taiwanese history among Taiwanese. Although this series of events started from a fictional novel, it focused on exploring histry and reconfirmed the tension between literature and reality. The novel 「Lady the Butterfly」 is based on a real event, the Rover incident, where an American merchant ship wrecked off the coast of Formosa in 1867 and left 14 sailors attacked by Taiwanese Aborigiens. The novel won the gold medal at 2016 Taiwanese Literature Awards and has been an object of interpretation in the academia. The author, Chen, emphasized that he writes with an objective to recreate the true history of Taiwan and that his works are not ‘historic novels’, but rather ‘novelized history’. He presents a pluralistic view and emphasizes the convergence of Taiwanese people. Critics of his work also talk about the truthfulness of history, not aesthetics of his work. This paper illustrates what kinds of narrative strategy Yaochang Chen uses to confer his pluralistic view and what kinds of questions he throws at literary and historic narratives through his original way of novel creation.

본 연구는 소비자가 경험재인 웹소설을 선택하는 상황에서 사실적 메시지와 평가적 메시지를 담은 온라인 리뷰를 보았을 때 더 유용하다고 판단하는 리뷰가 무엇인지 탐색하고, 이러한 유용성 평가의 차이에 대한 개인의 분석적 의사결정 성향 수준의 조절효과를 검증하기 위하여 실시되었다. 경험재를 구매하기 전 객관적 정보를 수집하는 소비 자의 성향에 근거하여 웹소설의 소비자는 사실적인 온라인 리뷰의 유용성을 더 높이 평가할 것으로 예상하였다. 또 한 인지적 성향에 따라 구분되는 의사결정 유형 중 분석적 의사결정자는 정확한 정보를 수집하여 논리적인 판단을 내린다. 따라서 분석적 의사결정 성향 수준이 높아짐에 따라 사실적인 온라인 리뷰의 유용성 평가가 높아질 것으로 예상하였다. 실험 1의 결과 사실적인 리뷰를 제시받은 집단이 평가적인 리뷰를 제시받은 집단보다 리뷰의 유용성을 높이 평가하였으며, 실제 웹소설 선택 상황과 유사하게 두 유형의 리뷰를 동시에 제시한 실험 2에서도 리뷰의 유용 성 평가에 대한 리뷰 메시지 유형의 주효과가 확인되었다. 또한 실험 2에서는 분석적 의사결정 성향 수준이 높아짐 에 따라 사실적인 리뷰의 유용성을 높이 평가하는 경향이 드러나 분석적 의사결정 성향 수준의 조절적 역할이 확인 되었다. 본 연구는 경험재인 웹소설을 선택하는 상황에서 리뷰 메시지 유형 및 소비자의 분석적 의사결정 성향 수준 이 소비자의 리뷰 유용성 평가에 영향을 끼친다는 사실을 확인함으로써 웹소설 소비자의 행동 양식을 밝혔다는 이론 적, 실무적 의의를 갖는다.

Two tree frogs, Dryophytes suweonensis and Dryophytes japonicus, inhabiting Korea, are morphologically similar and share the same habitats. Therefore, they are identified mainly through their calls, especially for males. Dryophytes suweonensis is registered as an endangered (IUCN: EN grade) and protected species in South Korea. Thus, it is necessary to develop a method to rapidly identify and discriminate the two species and establish efficient protection and restoration plans. We identified significant genetic variation between them by sequencing a maternallyinherited mitochondrial 12S ribosomal DNA region. Based on the sequence data, we designed a pair of primers containing 7 bp differences for high resolution melting (HRM) analysis to rapidly and accurately characterize their genotypes. The HRM analysis using genomic DNA showed that the melting peak for D. suweonensis was 76.4±0.06°C, whereas that of D. japonicus was 75.0±0.05°C. The differential melt curve plot further showed a distinct difference between them. We also carried out a pilot test for the application of HRM analysis based on immersing D. suweonensis in distilled water for 30 min to generate artificial environmental DNA (eDNA). The results showed 1.10-1.31°C differences in the melting peaks between the two tree frog samples. Therefore, this HRM analysis is rapid and accurate in identifying two tree frogs not only using their genomic DNA but also using highly non-invasive eDNA.

This study explains the han-ok. in Gae-sung, which was antique and traditional city. In view of the fact that these were located in Gae-sung in North Korea hence direct investigate is not possible. Since there was no comprehensive study of Gaeseong han-ok, we have no choice but to rely on fragmentary records and memory of Gaeseong people. In accordance from the Japanese colonial era's surveys and sketches as well as how they were illustrated in the novel. Hark back to the peoples' thought of the han-ok years when they ran the survey in 1920s, the results were as follows: First, there are many houses so various classes in Mi-Mang. Jeon Cheo-man’s house was a representative example of a rich family in Gae-sung, Jeon Je-seong(Jeon’s 2nd son)’s house was located in Si-jeon(government licensed-markets) near by the South gate. In particular, Jeon Yi-seong(Jeon’s 3rd son)’s house was in rural areas. He managed on immense ginseng field and worker’s houses. Hae-ju's house was a small house off the track. Second, the outer house is low and the main house is high and neat. Lastly, it was confirmed that it corresponded to sketches recorded by architects, such as neat housekeeping, long stones used for various purposes, invisible flat gates, the appearance of old and old houses and the composition of each room.

본 연구는 우리나라 해안에서 널리 서식 중인 해양 자원 중 하나인 전복(Haliotis discus hannai) 의 차세대염기서열분석 데이터 기반으로 선별한 신규 펩타이드의 항암 활성을 평가한 연구이 다. 펩타이드의 항암 활성은 교모세포종 세포주인 SNU-489에서 농도 의존적으로 처리 시간에 비례하여 증가하였으며, 200 μM로 48시간 처리하였을 때 암 세포 사멸율이 67%로 가장 높게 나타났다. 반면 정상 세포인 HaCaT에서 가장 높은 세포 사멸율은 18%로 농도 의존적이었으나 처리 시간과는 무관하였다. 또한 신규 펩타이드의 항암 메커니즘 과정을 밝히기 위해 세포자 멸괴사(Necroptosis) 관련 유전자의 발현 변화를 qRT-PCR 방법을 통해 검증하였다. RIPK3는 신 규 펩타이드 처리군에서 200 μM 처리 시 9배 이상 발현 증가, MLKL는 100 μM 처리군에서 대조군 대비 2배 이상 유의미하게 발현이 증가되었다. 이러한 결과로 미루어 볼 때, 전복 유래 신규 펩타이드는 암 세포 특이적으로 세포 독성을 가지며, 세포자멸괴사 메커니즘을 통해 암 세포 사멸을 일으키는 것으로 추측되므로 신규 펩타이드가 추후 교모세포종 치료제의 후보 물질로 활용될 수 있을 것으로 사료된다.

99Tc is a long-lived radioactive fission product whose mobility in the subsurface is largely governed by its oxidation state. Migration of Tc from a waste repository may be prevented by immobilizing Tc(IV) in durable glass forms. Thus, efficient incorporation and high retention of Tc by glasses is very important for radioactive waste management and environmental remediation. Tc(IV) oxidation to higly volatile Tc(VII) (TcO4 −) at glass vitrification temperatures results in poor Tc retention in the final waste glass. Retention of Tc in the glass is generally improved by reducing conditions since Tc(IV) is not volatile. However, experiments with Tc-magnetite under high temperature and oxic conditions showed re-oxidation of Tc(IV) to volatile pertechnetate. To understand this phenomenon, we employed ab initio molecular dynamics simulations to study structural and electronic properties of Tc-incorporation in magnetite. The study provides the ramification of high temperature on Tc mobilization and changes of Tc retention in magnetite. Theory predictions also indicated enhanced Tc retention in the presence of 1st row transition metal dopants in Tc-incorporated magnetite that was confirmed by experiments. Furthermore, the overwhelming concentration of Cr(VI) co-mingled with Tc(VII) within the secondary waste form where Cr(VI) is more readily reduced than Tc(VII) by reduction potential metrics. Experiments with Tc-magnetite under high temperature and oxic conditions showed re-oxidation of Tc(IV) to volatile pertechnetate. Experiments also showed that magnetite transforms to maghematite resulting in disproportionation and re-oxidation of Tc. This transformation can be suppressed through incorporation of trace elements such as Co, Ni, Zn into magnetite forming spinel. In this talk, I will present results from ab initio molecular dynamics simulations and experiments on the structural and electronic properties of Tc and/or Cr incorporation in magnetite. I will also discuss the temperature effect on Tc/Cr mobilization and changes of Tc/Cr retention in magnetite. In addition, I will discuss the effect of Tc/Cr concentration and 1st row transition metal dopants on their incorporation in magnetite.

본 연구는 코로나19 사태로 대면 접촉을 기피하는 가운데 심리치료가 필요한 고위 험 성폭력사범에 대해 비대면으로도 실시가 가능한 글쓰기가 성폭력사범 치료에 효과 적인지 확인하였다. 성폭력사범이 치료프로그램에 대해 느끼는 심리적 불편감을 줄임 으로써 이들의 낮은 프로그램 반응성을 조절하는 것이 가능한지 확인하기 위한 목적 으로 실험연구를 수행하였다. 전국 교정 심리치료센터에서 치료 중인 고위험 성폭력 사범 중 선발된 32명을 대상으로 55회기의 비대면 글쓰기 및 집단상담 치료를 진행하 였다. 그 결과, 비대면 글쓰기는 강간통념을 감소시키고, 사건 및 자서전적 기억을 다 루는 모듈에서 심리적 불편감을 완화하는 조절적인 역할을 함으로써 성폭력사범의 프 로그램 반응성을 증가시켰다. 본 연구의 결과는 길어지는 팬데믹 상황에서도 치료가 필수적인 성폭력 사범들에게 필요한 부분이 무엇인지를 시사하고 있다.

The term cholangiocarcinoma (CC) refers to all tumors arising from bile duct epithelium. CCs are characterized by their rarity, difficulty in diagnosis, and overall poor prognosis. This leads to a paucity of data from which to define the natural history and optimal treatment regimens. Currently, surgical resection remains the only potentially curative treatment, but many patients develop recurrence. In addition, a limited number of patients can be candidates for curative resection at diagnosis. Therefore, chemotherapy is inevitable choice for the treatment of advanced CC. Gemcitabine plus cisplatin (GP) is considered a standard option for advanced biliary cancer. A randomized phase III trial (ABC-02 trial) showed the superiority of gemcitabine plus cisplatin over gemcitabine alone. Treatment with nab-paclitaxel plus gemcitabine-cisplatin prolonged median progression-free survival and overall survival vs. those reported for historical controls treated with gemcitabine-cisplatin alone in a phase II study of 60 patients with locally advanced unresectable or metastatic biliary tract cancer. Recent data of the ABC-06 trial has provided slight evidence for the use of second-line chemotherapy after progression on cisplatin plus gemcitabine combination. Other active regimens, that could be considered in patients who include have disease progression while receiving GP and who retain an adequate performance status, includes capecitabine plus cisplatin, liposomal irinotecan plus leucovorin-modulated fluorouracil and a fluoropyrimidine alone. We herein review recent published data regarding the use of palliative chemotherapies in CC patients, with a particular focus on novel cytotoxic agents.

척추동물과 유사하게 곤충도 인지질분해효소(phospholipase A2)의 촉매 작용으로 다양한 아이코사노이드를 합성한다. 그러나 일련의 아 이코사노이드 생합성과정은 척추동물과 차이를 보이는데, 이는 곤충의 인지질에는 전구물질인 아라키도닉산의 함량이 낮기 때문이다. 대신에 비 교적 풍부하게 존재하는 다가불포화지방산인 리놀레익산을 기반으로 사슬 연장 및 불포화반응으로 아라키도닉산을 합성하여 척추동물과 같이 아이코사노이드 전구물질로 이용하는 것 같다. 이렇게 해서 형성된 아라키도닉산은 다시 척추동물의 cyclooxygenase와 유사한 peroxynectin이 PGH2 형태의 프로스타글란딘(prostaglandin: PG) 전구물질을 형성하게 된다. 이후 여러 이성체 효소들의 특이적 반응에 의해 PGA2, PGD2, PGE2, PGI2, TXB2의 다양한 PG가 생성된다. 반면에 또 다른 형태의 아이코사노이드인 에폭시아이코사트리에노익산(epoxyeicosatrienoic acid: EET)은 척추동물과 유사한 단일산화효소의 산화반응으로 아라키도닉산을 전구물질로 5,6-EET, 8,9-EET, 11,12-EET, 14,15-EET를 형성하게 된다. 그러나 세 번째 아이코사노이드 부류인 류코트리엔(leukotriene)의 경우 곤충 체내 존재는 확인되었지만 생합성 과정은 아직 밝 혀지지 않았다. 이들 아이코사노이드가 곤충의 대사, 배설, 면역 및 생식에 관여하는 생리작용을 중개한다. 따라서 아이코사노이드 생합성 과정을 교란하는 물질 탐색은 새로운 살충제 개발 전략이 된다. 본 종설은 이 가운데 PG의 곤충 면역 중개 기작을 소개한다.

In this paper, the performance evaluation of Al-graphene nanoplatelets (GNP) composites surface engineered by a modified friction stir processing (FSP) is reported. Here, multiple micro channels (MCRF) are used to incorporate GNPs in the aluminium matrix instead of a single large groove (SCRF) that is usually used in conventional FSP. With the MCRF approach, ~ 18% higher peak temperature (compared to SCRF) was observed owing to the presence of aluminium sandwiched between consecutive microgrooves and higher heat accumulation in the stir zone. The MCRF approach have significantly reduced the coefficient of friction and wear rates of the processed composites by ~ 14% and ~ 57%, respectively as compared to the SCRF approach. The proposed reinforcement filling method significantly improves the particle dispersion in the matrix, which in turn changes the adhesion mode of wear in SCRF to abrasive mode in MCRF fabricated composites. The uniformly squeezed out GNP tribolayer prevented the direct metal to metal contact between composite and its counterpart which have effectively reduced the deterioration rates.