It is well documented that giant cells can be observed in some types of odontogenic tumors such as central odontogenic tumor and dentinogenic ghost cell tumor. However, the presence of stromal giant cells has only rarely been reported in ameloblastoma, although being the most common epithelial odontogenic tumor. In this study, we present a novel case of peripheral ameloblastoma associated with peripheral giant cell granuloma arising in the mandibular alveolar mucosa of a 65-year-old male patient. The possible pathogenesis of this combined lesion will be discussed, in addition to the review of previous reports of ameloblastoma accompanied by stromal giant cells.

Peripheral ameloblastoma, a rare and unusual variant of odontogenic tumor, representing 1% of all ameloblastomas. The extraosseous location is the peculiar feature of this type of tumor, which is otherwise similar to the classical ameloblastoma. This paper describes a case of peripheral ameloblastoma in a 43-year-old female affecting the left retromolar pad area of the mandible which was clinically diagnosed as a pyogenic granuloma. Histologically, the tumor showed of follicular ameloblastoma in continuity with a surface oral epithelium.