In this study, we evaluated the property change and relationship between hematological and biochemical parameters in exposure group and control group by multiple inhalation exposure, of NO2. In case of leukocyte, change of hematological property increased significantly in statistics (p<0.05) in mice experiment. in case of hematocrit of exposure group, it was of decreased significantly in statistics. the tendency of hemoglobin and hematocrit was similar to all for three case. in case of methmoglobin that of the exposure group in mice experiment was meaning increased(p<0.05). For the NO2 influence in biochemical property, total protein and triglyceride was decreased but not significant in statistics, albumin was decreased in the exposure group in the animal experiments. blood urea nitrogen and creatinine increased significantly in statistics in the animal experiments. uric acid and lactate dehydrogenase in serum increased significantly in the exposure group. We have to evaluate risk assessment for the NO2 of indoor air pollutant in low concentration and long time.

This study evaluated the hazard caused by NO2, an oxidant generated in the process of welding. We compared hematological and biochemical parameters in workers who chronically inhale NO2 and office workers not exposed to NO2. NO2 exposure affected the hematological and biochemical parameters. Increasing NO2 concentrationincreased the number of leukocytes, while decreasing the number of erythrocytes. Blood urea nitrogen, creatinine, uric acid, and lactate dehydrogenase were increased, while total protein and triglycerides were decreased. The mean concentration of NOx(NO2-/ NO3-) in the serum of welders and the control group was 35.97±2.85 and 55.40±5.81 μmol/L, respectively. The difference was significant (p<0.05), although NO2- was not detected in the serum.