CIS nations are recognized as a emerging market recently because there are abundant natural resources and a lots of investment demand. Furthermore, they are located in the middle of Europe and Asia and that make them have more strategic importance as a logistics hub. So many global companies including domestic ones began to advance into the on-site. and henceforth this tendency will be strong. On the contrary, a research in logistics environment of CIS has rarely been done. This paper provides a way of systematic approach to design logistics network in CIS with real business case and shows the analyzed result of optimization simulation that includes factors have a huge influence on the overall logistics cost.