During wartime, the operation of engineering equipment plays a pivotal role in bolstering the combat prowess of military units. To fully harness this combat potential, it is imperative to provide efficient support precisely when and where it is needed most. While previous research has predominantly focused on optimizing equipment combinations to expedite individual mission performance, our model considers routing challenges encompassing multiple missions and temporal constraints. We implement a comprehensive analysis of potential wartime missions and developed a routing model for the operation of engineering equipment that takes into account multiple missions and their respective time windows of required start and completion time. Our approach focused on two primary objectives: maximizing overall capability and minimizing mission duration, all while adhering to a diverse set of constraints, including mission requirements, equipment availability, geographical locations, and time constraints.

In the (3,3) close combat model based on the Lanchester Square Law, this study proposes a plan to optimally allocate residual combat power after the battle to other battlefields. As soon as the two camps of three units can grasp each other's information and predict the battle pattern immediately after the battle began, the Time Zero Allocation of Force (TZAF) scenario was used to initially allocate combat power to readjust the combat model. It reflects travel time, which is a "field friction" in which physical distance exists from battlefields that support combat power to battlefields that are supported. By developing existing studies that try to examine the effect of travel time on the battlefield through the combat model, this study forms a (3,3) combat model, which is a large number of minimum units. In order to achieve the combat purpose, the principle of optimal combat force operation is presented by examining the aspect that support combat power is allocated to the two battlefields and the consequent battle results. Through this, various scenarios were set in consideration of the travel time and the situation of the units, and differentiated results were obtained. Although the most traditional, it can be used as the basic logic of the training or the commander's decision-making system using the actual war game model.

Maintaining sea superiority through successful mission accomplishments of warships is being proved to be an important factor of winning a war, as in the Ukraine-Russia war. in order to ensure the ability of a warship to perform its duties, the survivability of the warship must be strengthened. In particular, among the survivability factors, vulnerability is closely related to a damage assessment, and these vulnerability data are used as basic data to measure the mission capability. The warship's mission capability is usually measured using a wargame model, but only the operational effects of a macroscopic view are measured with a theater level resolution. In order to analyze the effectiveness and efficiency of a weapon system in the context of advanced weapon systems and equipments, a warship's mission capability must be measured at the engagement level resolution. To this end, not the relationship between the displacement tonnage and the weight of warheads applied in the theater level model, but an engagement level resolution vulnerability assessment method that can specify physical and functional damage at the hit position should be applied. This study proposes a method of measuring a warship’s mission capability by applying the warship vulnerability assessment method to the naval engagement level analysis model. The result can be used as basic data in developing engagement algorithms for effective and efficient operation tactics to be implemented from a single unit weapon system to multiple warships.

The primary therapeutic approach for Brucella species infections has mainly been based on antibiotic treatment. However, the development of vaccines for brucellosis control remains controversial. Furthermore, there is currently no licensed vaccine available for human brucellosis. This study aims to evaluate the effect of a combination of recombinant protein vaccines against Brucella (B.) abortus infection using a mouse model. Two B. abortus genes, namely dapB and gpm, were cloned and expressed in competent Escherichia (E.) coli DH5α using the pCold-TF vector. Successfully cloned vectors were subjected to PCR amplification using specific primer pairs. The apparent sizes of dapB and gpm were detected at 807 bp and 621 bp, respectively. Besides, the purified recombinant proteins dapB and gpm were detected using SDS-PAGE electrophoresis with correct sizes of 82.86 kDa and 87.61 kDa, respectively. These recombinant proteins were used to immunize mice as a combined subunit vaccine (CSV) to elicit host immunity against B. abortus infection. Mice immunized with CSV exhibited increased proliferation of CD4+ and/or CD8+ T cells at week 7th and 9th before sacrifice, in comparison to the control group. Notably, CSV immunization showed a significant decrease in bacterial burden in the spleen compared to the control group. Altogether, CSV using dapB and gpm induced host adaptive immune response against Brucella infection, suggesting its potential as an effective new subunit vaccine candidate.

In contemporary global warfare, the significance and imperative of air transportation have been steadily growing. The Republic of Korea Air Force currently operates only light and medium-sized military cargo planes, but does not have a heavy one. The current air transportation capability is limited to meet various present and future air transport needs due to lack of performance such as payload, range, cruise speed and altitude. The problem of population cliffs and lack of airplane parking space must also be addressed. These problems can be solved through the introduction of heavy cargo planes. Until now, most studies on the need of heavy cargo plane and increasing air transport capability have focused on the necessity. Some of them suggested specific quantity and model but have not provided scientific evidence. In this study, the appropriate ratio of heavy cargo plane suitable for the Korea's national power was calculated using principal component analysis and cluster analysis. In addition, an optimization model was established to maximize air transport capability considering realistic constraints. Finally we analyze the results of optimization model and compare two alternatives for force structure.

This study endeavors to enrich investment prospects in cryptocurrency by establishing a rationale for investment decisions. The primary objective involves evaluating the predictability of four prominent cryptocurrencies – Bitcoin, Ethereum, Litecoin, and EOS – and scrutinizing the efficacy of trading strategies developed based on the prediction model. To identify the most effective prediction model for each cryptocurrency annually, we employed three methodologies – AutoRegressive Integrated Moving Average (ARIMA), Long Short-Term Memory (LSTM), and Prophet – representing traditional statistics and artificial intelligence. These methods were applied across diverse periods and time intervals. The result suggested that Prophet trained on the previous 28 days' price history at 15-minute intervals generally yielded the highest performance. The results were validated through a random selection of 100 days (20 target dates per year) spanning from January 1st, 2018, to December 31st, 2022. The trading strategies were formulated based on the optimal-performing prediction model, grounded in the simple principle of assigning greater weight to more predictable assets. When the forecasting model indicates an upward trend, it is recommended to acquire the cryptocurrency with the investment amount determined by its performance. Experimental results consistently demonstrated that the proposed trading strategy yields higher returns compared to an equal portfolio employing a buy-and-hold strategy. The cryptocurrency trading model introduced in this paper carries two significant implications. Firstly, it facilitates the evolution of cryptocurrencies from speculative assets to investment instruments. Secondly, it plays a crucial role in advancing deep learning- based investment strategies by providing sound evidence for portfolio allocation. This addresses the black box issue, a notable weakness in deep learning, offering increased transparency to the model.

Approximately 40,000 elevators are installed every year in Korea, and they are used as a convenient means of transportation in daily life. However, the continuous increase in elevators has a social problem of increased safety accidents behind the functional aspect of convenience. There is an emerging need to induce preemptive and active elevator safety management by elevator management entities by strengthening the management of poorly managed elevators. Therefore, this study examines domestic research cases related to the evaluation items of the elevator safety quality rating system conducted in previous studies, and develops a statistical model that can examine the effect of elevator maintenance quality as a result of the safety management of the elevator management entity. We review two types: odds ratio analysis and logistic regression analysis models.

Iron is an essential nutrient for mammalian cells. Most iron absorption occurs in the duodenal epithelial cells and is regulated by hepcidin, which is produced and secreted in the liver. High hepcidin levels can cause iron deficiency anemia due to iron absorption failure. Inside the cell, iron conjugates with a porphyrin ring and is placed with an iron coordinated to heme. One of the heme-binding proteins, known as progesterone receptor membrane component 1 (Pgrmc1), is a non-canonical progesterone receptor associated with diverse molecular gene regulation. Previous studies showed that Pgrmc1 is related to iron homeostasis via hepcidin; however, these mechanisms remain to be elucidated. In the present study, to investigate the role of Pgrmc1 in mammalian iron metabolism, we introduced Pgrmc1 knockout (KO) mice and performed molecular biological analyses using qPCR and western blotting. Pgrmc1 deficiency decreased Hamp mRNA expression and hepcidin protein levels. However, Pgrmc1 deficiency failed to decrease Hamp transcript expression and hepcidin protein levels in siPGRMC1-transfected HepG2 cells and primary Pgrmc1 KO hepatocytes, respectively. PGRMC1 knockdown cells revealed low HAMP mRNA levels upon cyclic AMP (cAMP) activation, suggesting that PGRMC1 promotes HAMP mRNA transcription via cAMP activation. It has been implicated that hepatic Pgrmc1 cannot control hepcidin directly; however, the internal environment caused by the lack of Pgrmc1 may potentially cause low hepcidin levels.

본 연구는 테이블 탑 보드게임 개발 방법론인 CDR 모델을 제안하여 보드게임 개발과정에서의 어려움을 일 부 해소하고 나아가 디자이너가 개발 경험을 지속할 수 있는 토대를 마련하는 것이 목적이다. 이를 위해 보 드게임 개발 방법론인 CDR 모델을 설계하고 보드게임 개발 경험이 있는 전문가 패널 15명을 대상으로 인터 뷰를 진행하였다. 연구 결과 CDR 모델이 기존의 개발 방법론보다 체계적인 개발이 가능하도록 설계되어 개 발 시 단계별 작업 내용을 확인하고, 오류를 줄이면서 누락내용 없이 개발이 가능한 것으로 나타났다. 본 연 구에 의한 CDR 모델을 통해 보드게임을 만들고자 하는 디자이너는 보드게임을 디자인하는 데 있어서 가장 중요한 게임요소와 그것을 어떻게 부각할지에 대한 고민을 해결하고 개발을 지속할 수 있는 토대를 마련하 는 데 도움이 될 것으로 기대한다.

Effects-Based Operations (EBO) refers to a process for achieving strategic goals by focusing on effects rather than attrition-based destruction. For a successful implementation of EBO, identifying key nodes in an adversary network is crucial in the process of EBO. In this study, we suggest a network-based approach that combines network centrality and optimization to select the most influential nodes. First, we analyze the adversary’s network structure to identify the node influence using degree and betweenness centrality. Degree centrality refers to the extent of direct links of a node to other nodes, and betweenness centrality refers to the extent to which a node lies between the paths connecting other nodes of a network together. Based on the centrality results, we then suggest an optimization model in which we minimize the sum of the main effects of the adversary by identifying the most influential nodes under the dynamic nature of the adversary network structure. Our results show that key node identification based on our optimization model outperforms simple centrality-based node identification in terms of decreasing the entire network value. We expect that these results can provide insight not only to military field for selecting key targets, but also to other multidisciplinary areas in identifying key nodes when they are interacting to each other in a network.

Sucralose는 식품 분야에서 sucrose 대체물로 사용되며 세계적으로 승인된 무열량 고강도 인 공 감미료이다. 하지만 감미료가 뇌에 미치는 영향에 대한 조사는 미비하여 본 연구에서 scopolamine으 로 유발된 기억력 손상 동물모델에서 sucralose 단기 섭취가 인지 및 기억 보호 효과를 가지는지 확인하 였다. Sucralose 2, 5, 10 mg/kg를 경구투여하였으며 30분 후 대조군, 약물군에 scopolamine (1mg/kg) 복강투여를 진행하였고 정상군에는 식염수로 복강투여 후 행동실험을 수행하였다. 결과적으로 Y-maze, passive avoidance, Morris water maze에서 대조군과 비교해 10% 이상의 인지기능이 회복되는 결과를 도출하였다. 또한, 전염증성 사이토카인을 측정한 결과 sucralose가 IL-6와 TNF-α를 30% 이상 억제 하는 것을 보였으며 세포 내 신호 메커니즘으로 ERK-CREB의 발현량을 관찰한 결과 농도 의존적으로 증가하였다. 따라서 sucralose는 건망증 환자의 예방과 치료를 위한 기능성 식품과 관련이 있다고 시사 된다.

본 글의 목적은 민주시민교육과 통일교육이 서로 충돌하지 않는 조화 로운 관계모델을 정립하기 위하여 이론적인 차원에서 민주시민교육과 통 일교육의 관계유형을 논의하고, 바람직한 유형을 <민주시민교육-통일교 육 상호보완형 모델>로 설정하여 이것에 대한 적절한 경험적 사례로 서 독 연방정치교육원의 정치교육 사례를 분석하여 이것이 우리에게 주는 시사점을 찾는 데 있다. <민주시민교육-통일교육 상호보완형 모델>이 강 조하는 내용은 다음과 같다. 우선 통일교육과 통일정책을 구분한 상태에 서 민주시민교육의 내용은 자유공화주의적 규범에 근거한 아시아 지역정 체성을 형성하는 ‘지역통합’을 강조하는 게 필요하다. 그리고 통일교육의 내용은 통일의 필요성을 강조하는 교육보다는 바람직한 통일의 방법론과 평화적 교류협력 같은 정책을 소개하는 교육이 필요하다.

4차 산업혁명의 도래로 인한 기술혁신은 자율운항선박을 중심으로 해상 운송분야까지 활발한 발전을 불러왔다. 특히, 현재의 선원이 직접 운항하는 방식인 유인선박 사이에서 운항하게 될 자율운항선박은 자율도에 따라 원격제어를 통해 운항을 수행하며, 육상에 서 이를 제어할 원격운항자에 대한 관심 또한 늘어나고 있다. 하지만 아직 원격운항자가 개입이 필요한 상황이 동시에 발생하는 등을 고 려한 원격운항자 최소 인력 요구사항에 대한 연구는 부족한 상황이다. 본 연구는 특정 해역 구간의 누적된 항적데이터를 활용하여 선박 간에 발생할 수 있는 조우상황에서 원격운항자의 개입이 필요한 상황을 정의하고, 해당 구간을 특정 규모의 자율운항선박 선대로 운항하 였을 때, 원격운항자의 개입이 동시에 필요한 상황이 얼마나 발생하는지를 시뮬레이션을 통해 확인하였다. 연구의 결과는 향후 실제 자율 운항선박 선대를 운행할 원격운항센터의 원격운항자의 적정인력 배치 등의 계획 또는 정책 수립에 활용될 기초 자료로 활용될 것으로 기 대한다.

해상교통관제센터(VTS)의 관제사는 구역 내 교통 상황을 빠르고 정확하게 파악하여 관제가 필요한 선박에게 정보를 제공하는 역할을 수행한다. 그러나 교통량이 급격히 증가하는 경우 관제사의 업무 부하로 인해 관제 공백이 발생하기도 한다. 이러한 이유에서 관 제사의 업무 부하를 줄이고, 일관성 있는 관제 정보를 제공할 수 있는 관제 지원 기술의 개발이 필요한 실정이며, 본 논문에서는 구역 내 이상 운항 선박을 자동으로 식별하는 모델을 제안하였다. 제안하는 이상 운항 식별 모델은 규칙 기반 모델, 위치 기반 모델, 맥락 기반 모 델로 구성되며, 대상 해역의 교통 특성에 최적화된 교통 네트워크 모델을 사용하는 특징이 있다. 구현된 모델은 시범센터(대산항 VTS)에 서 수집되는 실해역 데이터를 적용하여 실험을 수행하였다. 실험을 통해 실해역의 다양한 이상 운항 상황이 자동으로 식별됨을 확인하였 고, 전문가 평가를 통해 식별 결과를 검증하였다.

기후변화는 연안지역에 심각한 영향을 미치고 있으며 그 영향이 점점 증가할 것이라고 예상되는 바, 최근 기후변화 적응 및 리스크 평가에 있어 많은 연구들이 취약성과 함께 회복탄력성 개념을 이용하고 있다. 본 연구의 목적은 기후변화 적응을 위한 연안재해 회복탄력성 측정 모형을 개발하는 것이다. 측정 모형 개발에 앞서 연안재해 회복탄력성에 대한 광범위한 문헌검토를 통해 취약성과 회복 탄력성에 대한 조작적 정의와 함께 여러 피드백 메커니즘이 포함된 개념적 프레임워크를 작성하였다. 연안재해 회복탄력성 측정 모형은 네 가지 측정값(MRV, LRV, RTSPV, ND)과 연안재해 회복탄력성 복합 지수(CRI)를 포함하고 있으며, 개발된 지수는 국내 연안침식 사례에 적용되었다. 또한 지수 등급에 따른 지역적 분석이 수행되었다. 연구 결과, 네 가지 회복탄력성 측정값을 통해 각 지점이 가지는 연안침식 회복탄력성의 다양한 특성을 파악할 수 있음을 확인하였다. 연안 회복탄력성 복합 지수의 매핑 결과 서해안 및 남해안 지역에 비해 동해 안 지역들은 연안침식 회복탄력성이 상대적으로 떨어지는 것으로 나타났다. 본 연구의 회복탄력성 측정 모형은 적응 이후의 이행전략에 대한 논의를 제공하는 도구로 활용될 수 있으며, 서로 다른 취약 지역 그룹 간 정책지원에 대한 우선순위를 결정하는 데 이용 가능하다.

2017년 7월 15일 서울과 수도권에 집중호우를 발생시킨 깊은 대류운과 강수 발달에 대한 종관 기상 메커니즘 을 규명하고 중국 동부지역으로부터의 PM2.5 에어로졸의 간접효과를 WRF-Chem 실험을 통해 분석하였다. WRF-Chem 모델에 에어로졸과 복사의 피드백, 구름 화학 과정, 습식 세정을 모두 포함한 ARI (Aerosol Radiation Interaction) 실험 과 에어로졸과 복사의 피드백을 제외하고 구름 화학 과정, 습식 세정만을 포함한 ACR (Aerosol Cloud Radiation interaction) 실험 결과의 차이로부터 PM2.5 에어로졸 간접효과를 산출하였다. 2017년 7월 15일 새벽에 황해와 한반도에 서는 동아시아 대륙에서 저기압-북서 태평양의 고기압 분포로 인해 중국 남동 지역과 동중국해로부터 덥고 습한 기류 가 수렴하고 있었다. 이러한 황해의 종관 기상에 의해 발달하는 대류운은 높이 12 km 이상이며 고체 수상체를 형성하 고 있었는데, 이는 주로 대륙 위에서 발달하는 한랭운(많은 빙정을 형성하며 운정고도가 8 km 이상)의 특성을 나타내고 있었다. 특히, WRF-Chem 모델 실험을 통해 중국 동부지역으로부터 확산하는 PM2.5 에어로졸이 구름물 형성에 5.7%, 고체 수상체 형성에 10.4%, 그리고 액체 수상체 형성에 10.8%로 대류운이 한랭운으로 발달하는 데 기여하고 있었다. 본 연구는 황해 위에서 깊은 대류운이 발달하는 과정에 대한 기상적 메커니즘과 더불어 중국 동부지역으로부터 에어로 졸에 의한 간접효과의 영향을 제시하였다.

In this study, we analyzed how the revenue water ratio(RWR) is affected by changes in conditions of the water supply area, such as the ratio of aging pipes, maintenance conditions, and revenue water. As a result of analyzing the impact of pipe aging and maintenance conditions on the RWR, it was confirmed that the RWR could be decreased if the pipe replacement project to improve the aging pipe ratio was not carried out and proper maintenance costs were not secured. It was also confirmed that an increase in the revenue water could be operated to facilitate the achievement of the project’s target RWR. In contrast, a decrease in the revenue water due to a population reduction could affect the failure of the target RWR. In addition to analyzing the causes of variation in the RWR, the calculation of estimated project costs was considered by using leakage reduction instead of RWR from recent RWR improvement project cost data. From this analysis, it was reviewed whether the project costs planned to achieve the target RWR of the RWR improvement project in A city were appropriate. In conclusion, the RWR could be affected by variations in the ratio of aging pipes, maintenance conditions, and revenue water, and it was reasonable to consider not only the construction input but also the input related to RWR improvement, such as leakage reduction, when calculating the project cost.

In this study, the biogeochemistry management (BGC-MAN) model was applied to North and South Korea pine and oak forest stands to evaluate the Net Primary Productivity (NPP), an indicator of forest ecosystem productivity. For meteorological information, historical records and East Asian climate scenario data of Shared Socioeconomic Pathways (SSPs) were used. For vegetation information, pine (Pinus densiflora) and oak (Quercus spp.) forest stands were selected at the Gwangneung and Seolmacheon in South Korea and Sariwon, Sohung, Haeju, Jongju, and Wonsan, which are known to have tree nurseries in North Korea. Among the biophysical information, we used the elevation model for topographic data such as longitude, altitude, and slope direction, and the global soil database for soil data. For management factors, we considered the destruction of forests in North and South Korea due to the Korean War in 1950 and the subsequent reforestation process. The overall mean value of simulated NPP from 1991 to 2100 was 5.17 Mg C ha-1, with a range of 3.30-8.19 Mg C ha-1. In addition, increased variability in climate scenarios resulted in variations in forest productivity, with a notable decline in the growth of pine forests. The applicability of the BGC-MAN model to the Korean Peninsula was examined at a time when the ecosystem process-based models were becoming increasingly important due to climate change. In this study, the data on the effects of climate change disturbances on forest ecosystems that was analyzed was limited; therefore, future modeling methods should be improved to simulate more precise ecosystem changes across the Korean Peninsula through processbased models.

This study was conducted to investigate the growth characteristics of domestic 'Sulhyang' strawberry (Fragaria × ananassa Duch.) seedlings and to analyze their relationships in order to develop a growth prediction model. Fresh weight, dry weight, and leaf area were measured to validate the newly developed growth model. The relative growth rate (RGR) of ‘Sulhyang’ seedlings’ dry weight was an average of 0.026 g·g-1·d-1, and it increased to 0.066 g·g-1·d-1 on the 49th day after transplanting (DAT). The relationship between DAT and RGR was represented as RGR (dry weight)(g·g- 1·d-1) = 0.0392/(1 + exp(–(DAT – 34.9940)/5.8662)). The crop growth rate (CGR) was an average of 0.060 g·m-2·d-1, and it increased to 0.211 g·m-2·d-1 on the 70th DAT. The relationship between DAT and CGR was calculated as CGR (dry weight)(g·m-2·d-1) = 0.1293/(1 + exp(–(DAT – 49.3917)/6.0928)). The relationship between shoot fresh weight (y) and shoot dry weight (x) per plant showed a linear relationship of y = 4.3189x + 0.7812 (R2 = 0.9976). Fresh weight, dry weight, and leaf area with respect to DAT and cumulative temperature increased exponentially, and sigmoid curve models were developed based on these data. The model with the highest coefficient of determination was found for the relationship between shoot dry weight (y) and cumulative temperature (x), represented as y = 14.2285/(1 + exp(–(x – 1590.1295)/377.8112)) (R2 = 0.9715). The results of this study can be utilized as valuable information for establishing a systematic management system for seedling production using strawberry cutting propagation methods. For the development of a more precise growth prediction model in the future, it is necessary to analyze and apply a wider range of growth indicators and meteorological factors related to strawberry seedlings.