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Antioxidant, anti-inflammatory and anticancer potential of Geranium sibiricum

  • 언어ENG
  • URLhttps://db.koreascholar.com/Article/Detail/242643
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단국대학교 국제농업협력연구소 (Dankook International Cooperation on Agriculture)
초록

This study was conducted to investigate the biomedicinal worth of different parts of Geranium sibiricum Antioxidant, anti-inflammatoty and anticancer activities of methanolic extracts of root and shoot of Geranium sibiricum were determined. Methanolic extracts of root and shoot parts of Geranium sibiricum had antioxidant activity in the range of 40-50 jlg mL·1, and shoot extract was best in this regard. Likewise, anti-inflammatory activities of extracts was in the range of 60-100 jlg mL-1 and root extract of Geranium sibiricum seemed more useful with 87.38% higher anti-inflammatory activity than shoot with 63.63% activity. Regarding cytotoxicty test against two cancer cell line i.e. SK-Hep1 (liver) and HeLa (uterus), the methanolic extracts of shoot and root of Geranium sibiricum showed the highest toxicity with IC50 values of 10-30 jlg mL-1 and root extract proved more beneficial in this regard. In conclusion, methanolic extract of shoot of Geranium sibiricum had higher antioxidant while root extract had higher anti-inflammatoty and anticancer activities.

저자
  • Eun-Jeong Lee(College ofBio-resource Science, Dankook University, Anseo-dong)
  • Ka-Hee Jang(College ofBio-resource Science, Dankook University, Anseo-dong)
  • Hye-Won Park(College ofBio-resource Science, Dankook University, Anseo-dong)
  • Seon-Yeong Im(College ofBio-resource Science, Dankook University, Anseo-dong)
  • Soo-Choul Lee(College ofBio-resource Science, Dankook University, Anseo-dong)
  • Dong-Jin Lee(College ofBio-resource Science, Dankook University, Anseo-dong) Corresponding authors