Antioxidant, anti-acetylcholinesterase and xanthine oxidase inhibitory activities of three extracts from Phellinus igniarius
- 언어ENG
- URLhttps://db.koreascholar.com/Article/Detail/276531
pp.1-7
This study was initiated to investigate antioxidant, anti-acetylcholinesterase, and xanthine oxidase inhibitory activities and properties of fruiting bodies, mycelia, and fermentation culture filtrates from Phellinus igniarius. The contents of total phenols and flavonoid of fruit bodies, mycelia, and culture filtrate were 15.35-1.36 mg/g, 10.35-7.85 mg/g, and 8.25-5.36 mg/g. The 1,1- diphenyl-1-picrylhydrazyl (DPPH) radical scavenging abilities of the extracts from the fruiting bodies, mycelia, and culture filtrates were 90.25-95.60%, 78.82-85.24%, and 76.32-82.50% at 50-400 μg/mL, respectively. The chelating ability of fruiting body extract on ferrous ions was higher than those of mycelia and culture filtrates tested. The anti-acetylcholinesterase inhibitory activity of the fruiting body extract at 400 μg/mg exhibited 91.10% on AChE, which is lower than that of positive control, galanthamine (94.82%). The xanthine oxidase inhibitory activities of the fruiting bodies, mycelia, and culture extract were 85.47%, 78.13%, and 72.49% at 400 μg/mL, respectively. Overall, the fruiting body extract has better anti-acetylcholinesterase, antioxidant and xanthine oxidase inhibitory activities than those from mycelia and culture filtrate.
Introduction
Materials and Methods
Specimens and fungal isolate
Preparation of the Extracts
Fruiting body extract
Mycelia extract
Culture filtrate
Assay for total phenolics
Assay for total flavonoid
Scavenging effect on DPPH radicals
Chelating effect on ferrous ions
Xanthine oxidase inhibitory activity
Acetylcholinesterase inhibitory activity
Results and Discussions
Total phenolics and flavonoid
DPPH scavenging effect on free radicals
Chelating effects on ferrous ions
Xanthine oxidase inhibitory activity
Acetylcholinesterase inhibitory activity
Acknowledgemen
References