KOREASCHOLAR

버섯류 추출물이 전립선 암 세포 내 PSA 발현에 미치는 영향 The effect of the mushrooms extract on the PSA expression in prostate cancer cells

김은경, 당옥교, 최희리, 최은주
  • 언어KOR
  • URLhttps://db.koreascholar.com/Article/Detail/307739
PDF 원문보기
한국버섯학회지
제13권 제3호 (2015.09)
pp.181-184
한국버섯학회 (The Korean Society of Mushroom Science)
초록

Mushroom have long been valued as highly nutritious and tasty foods in many societies throughout the world. Itis known for biological activities including anti-inflammatory and anti-oxidative potential. However little is known about anti-cancer property. In this study, we investigated the anti-prostate cancer activity of mushrooms. For that, eight kinds ofmushrooms such as, T. matsutake, S. crispa, G. lucidum-US, G. lucidum-AS, C. cardinalis-BR, G. frondosa, P. linteus, U.esculenta were extracted with hot water. Among them, three kinds of mushrooms including T. matsutake, G. lucidum-US andC. militaris-BR extracts inhibited prostate specific antigen (PSA) expression in prostate cancer cell, LNCaP. These resultsdemonstrate that some of mushrooms inhibited PSA expression suggesting that the mushrooms might be a candidate for thetreatment of prostate cancer.

키워드
LNCaPMushroomProstate cancerPSA
목차
서 론
 재료 및 방법
  버섯시료 추출 방법
  세포 배양
  RNA isolation
  RT-PCR (Reverse Transcription-Polymerase ChainReaction)
  정량적 역전사 반응(Real-time quantitative polymerasechain reaction, qPCR)
  PCR정량 분석
  통계처리
 결과 및 고찰
  전립선암세포(LNCaP)에서 8종 버섯류 열수 추출물의PSA mRNA 발현 억제효과
  전립선암세포(LNCaP)에서 참송이버섯, 편각영지버섯및 현미동충하초버섯 열수 추출물의 PSA mRNA 발현 억제효과
 적 요
 감사의 글
 References
저자
  • 김은경(건국대학교 식품생명과학부) | Eun-Kyung Kim
  • 당옥교(건국대학교 식품생명과학부) | Yujiao Tang
  • 최희리(건국대학교 스포츠과학부) | Heeri Choi
  • 최은주(건국대학교 스포츠과학부) | Eun-Ju Choi Corresponding author