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ent-Kaurane-and ent-Pimarane-Type Diterpenoids from Siegesbeckia pubescens and Their Cytotoxicity in Caki Cells KCI 등재
Sanghyun Lee, Eun Jung Noh, Jung Sook Kim, Eun Mi Son, Xu Pan, Yeong Shik Kim, Bak-Kwang Kim, Burm-Jong Lee
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- URLhttps://db.koreascholar.com/Article/Detail/13784
한국작물학회지
(Korean Journal of Crop Science)
제50권 2호 (2005.06)
pp.147-150
pp.147-150
한국작물학회
(Korean Society Of Crop Science)
초록
ent-Kaurane- and ent-pimarane-type diterpenoids were isolated from the methanol extract of Siegesbeckia pubescens by column chromatography. Their structures were elucidated as ent-16α H,17-hydroxy-kauran-19-oic acid (1), ent-4,17-dihydroxy-16α -methyl-kauran-19-oic acid (2), ent-16β ,17-dihydroxy-kauran-19-oic acid (3), kirenol (4) and ent-16β ,17,18-trihydroxy-kauran19-oic acid (5) by spectral analysis. The cytotoxicity of these compounds in Caki cells was assayed by a cell counting kit. Only one group treated with kirenol (4), an entpimarane-type diterpenoid, showed the inhibition of the cell growth in Caki cells.
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