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Expression Profiling of Genes involved in the Control of Pluripotency Using CDNA Microarray

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  • URLhttps://db.koreascholar.com/Article/Detail/1622
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한국발생생물학회 (The Korea Society Of Developmental Biology)
초록

To identify genes implicated in the control of pluripotency as well as characteristics of stem cells, we analyzed expression profiles of genes derived from mouse morulas, blastocysts, embryonic stem cells, mesenchymal stem cells, and uterus tissue cDNA microarray. Comparative analyses of their expression profiles identified putative clones that expressed specifically in specific samples or not in a specific sample. The expression pattern of these candidate clones was analyzed using RT-PCR and non-radioactive in situ hybridization. Functional annotation of these clones on pluripotency and stem cells and molecular mechanisms underlying many facets of mammalian development and differentiation.

저자
  • Lee Young-Jin
  • Hong Seok-Ho
  • Nah Hee-Young
  • Chae Jai-Hyung
  • Jung Ho-Sun
  • Kim Beom-Sue
  • Kim Chul-Geun