This study aims to examine the effect of Genetically Modified β -Carotene Biofortified Rice rice developed by simultaneous expression technology in NAAS on biological immunity. Accordingly, this study added Genetically Modified β-Carotene Biofortified Rice 25, 50% and general rice 50% as control group into diet and provided rats with the prescribed feeds and then measured the contents of immunoglobulin and cytokine in blood. As a result, male and female IgM, IgE, male IgG1, female IgG2a and TNF-a, IL5 and IL12 showed no significant difference; male IgG2a tended to decrease dependently on the combined concentration of Genetically Modified β-Carotene Biofortified Rice; female IgG1 showed significance with control group, but its association with diet was not found. The higher the dietary mixing ratio, the more the male and female IFN-a and female IL-4 contents, regardless of rice variety, and it was found that female IL6 content decreased significantly, but its association with diet was not found. The risk of beta carotene-enriched rice into environment and human body has not been reported yet. The digestion of Genetically Modified β-Carotene Biofortified Rice can be seen as "safe" as this test result showed no big difference between general rice and Genetically Modified β-Carotene Biofortified Rice, and its usability is full of suggestions.

ABSTRACT   INTRODUCTION   MATERIALS AND METHODS    Materials and Feed    Study Animals    Analysis of the Blood Sample    Analysis of Immunogloblin and Cytokine    Statistical Analysis   RESULTS    Weight and Feed Intake Amount    Analysis of Blood Sample    Measurement of the Contents of Immunoglobulin and Cytokine   DISCUSSION   REFERENCES

• Soo Jin Park(Agro-Material Safety Evaluating Division, Department of Agro-Food Safety, National Academy of Agricultural Science, Rural Development Administration, Suwon 441-707, Korea)
• Mihye Jeong(Agro-Material Safety Evaluating Division, Department of Agro-Food Safety, National Academy of Agricultural Science, Rural Development Administration, Suwon 441-707, Korea) Corresponding author
• Kyung-Hun Park(Agro-Material Safety Evaluating Division, Department of Agro-Food Safety, National Academy of Agricultural Science, Rural Development Administration, Suwon 441-707, Korea)
• Jae-Eup Park(Agro-Material Safety Evaluating Division, Department of Agro-Food Safety, National Academy of Agricultural Science, Rural Development Administration, Suwon 441-707, Korea)