Evolutionary processes such as recombination and natural selection usually develop over extended periods of time; however, they get accelerated in cases of hybridization. Interspecies hybrids exhibit novel genome which are exposed to natural selection, thus provides a key to unravel the ultimate causes of adaptation and speciation. On the other hand, with rapid upsurge in demand for stronger food security has been confronting us on daily basis. Lately, the scientists have started to gather are now attracted by specific extraordinary traits of different animals by way interspecies hybridization combining the superior genetic material from different animals. Besides, this technology could also explore new life saving vaccines and medicines and also would find beneficial in conserving wild heritage of endangered and critical species. Several researchers have also done commendable work on interspecies hybridization with some degree of success. Nevertheless, lots of obstacles and hurdles still pose for this phenomenal technology to reach to its final destination. This review will point out the hurdles on interspecies hybridization in reference to the natural mating and somatic cell nuclear transfer (SCNT).

ABSTRACT   INTRODUCTION   Interspecies hybridization and hybrid   Advantages of Interspecies hybridization   Disadvantages of interspecies hybridization   Hurdles in interspecies hybridization    Isolation Mechanism    Inability to invade oocyte wall by sperm    Adverse effect of the Oviductal factors    Polarity in Hybridization    Large fetus size    Unavailability of suitable foster mother    Failure to Nuclear Reprogramming    Mitochondrial/genomic DNA incompatibility    Zygotic Genome Activation (ZGA) Failure    Improper placenta formation and maternal immune response   Interspecies Hybridization and Future AnimalProduction   Conclusion   LITERATURE CITED

• 아부 무사 레자(강원대학교 동물생명과학대학) | Abu Musa Md. Talimur Reza
• 이성진(강원대학교 동물생명과학대학) | Sung-Jin Lee
• 나레시쿠마 싱(강원대학교 동물생명과학대학) | Naresh Kumar Singh Corresponding author