Worldwide there is concern about the continuing release of a broad range of environmental endocrine disrupting chemicals, including polychlorinated biphenyls, dioxins, phthalates, polybrominated diphenyl ethers (PBDEs), and other halogenated organochlorines persistent organic pollutants (POPs) into the environment. They are condemned for health adverse effects such as cancer, reproductive defects, neurobehavioral abnormalities, endocrine and immunological toxicity. These effects can be elicited via a number of mechanisms among others include disruption of endocrine system, oxidation stress and epigenetic. However, most of the mechanisms are not clear, thus several number of studies are ongoing trying to elucidate them in order to protect the public by reducing these adverse effects. In this review, we briefly limited review the process, the impacts, and the potential mechanisms of dioxin/dioxin like compound, particularly, their possible roles in adverse developmental and reproductive processes, diseases, and gene expression and associated molecular pathways in cells.

• Thuy Thi Bich Vo(Institute of Genome Research)
• Binh Thi Nguyen Le(Institute of Genome Research)
• Hai Van Nong(Institute of Genome Research)
• Hyun Yang(Laboratory of Veterinary Biochemistry and Molecular Biology)
• Eui-Bae Jeung(Laboratory of Veterinary Biochemistry and Molecular Biology)