방사선이 조사된 세포막 모델에서 K+와 Na+의 능동전달 효과에 대해서 연구하였다. 이 실험에 사용된 세포막 모델 은 스티렌과 디비닐벤젠의 슬폰화 혼성중합막이다. 이온의 초기플럭스는 양쪽의 H+ 이온농도 증가와 함께 증가하였다. 실험범위 pH 0.5-3에서 방사선이 조사되지 않은 막의 K+의 초기 플럭스는 7.9x10-4 -7.49x10-3 mole/cm2․ h이고 Na+의 초기 플럭스는 10.6x10-4 - 7.68x10-3 mole/cm2․ h이다. 방사선이 조사된 막의 K+의 초기 플럭스는 35.0x10-4 - 42.4x10-3 mole/cm2․ h 이고 Na+의 초기 플럭스는 52.0x10-4 - 43.3x10-3 mole/cm2․ h이다. 막은 K+를 선택하였고 K+/ Na+의 비는 약 1.1이다. 조사된 막의 pH의 구동력은 조사되지 않은 막보다 약 3-4배 정 도 유의 있게 증가하였다. 세포막 모델의 K+와 Na+의 능동전달이 비정상적이기 때문에 세포장해가 세포에서 나타나게 된다.

The effect on active transport of K+ and Na+ of cell membrane model which irradiated by radiation was investigated. The cell membrane model used in this experiment was a Na+ type sulfonated copolymerized membrane of styrene and divinylbenezene. The initial flux of the ion was increased with increase of both H+ ion concentration. In this experiment range(pH 0.5-3), the initial flux of K+ which was not irradiated by radiation was found to be from 7.9x10-4 to 7.49x10-3 mole/cm2․ h and that of Na+ from 10.6x10-4 to 7.68x10-3 mole/cm2․ h. The initial flux of K+ which was irradiated by radiation was found to be from 35.0x10-4 to 42.4x10-3 mole/cm2․ h and that of Na+ from 52.0x10-4 to 43.3x10-3 mole/cm2․ h. The membrane was selective for K+ and the ratio K+/Na+ was about 1.10. And the driving force of pH of irradiated membrane was significantly increased about 4-5 times than membrane which was not irradiated. As active transport of K+ and Na+ of cell membrane model were abnormal, cell damages were appeared at cell.

• 고인호(제주한라대학 방사선과) | Inho Ko
• 여진동(서라벌대학 방사선과) | Jindong Yeo Corresponding Author