Leibniz was trying in his whole life to establish mutual understanding and cooperation in many respects, especially between the east and the west. This paper focuses on philosophy of mind in both Confucianism and Leibniz's organism. On the one hand, the two are almost in consonance with each other. Firstly, in the point of mind, Confucianism shows that mind has the characteristic of subjectivity and has a process for self-fulfilment as well. In Leibniz's organism, mind refers to the rational soul, which has the ability of introspection. Secondly, in the point of man, for Confucianism, man has morality, which distinguishes man from beast. For Leibniz, it is alike that man has self-awareness, which makes man to be man. On the other hand, the two are quite different. In the point of the relationship between mind and object, as well as man and the nature, Confucianism holds that mind and object is a unity. Man is an integral part of the nature natively. Nevertheless, as for Leibniz, mind and object are separated. Orders were set up by preestablished harmony. In summary, Confucianism and Leibniz have both the similar and different arguments on mind, which lay exactly the foundation for the dialogue and study between each other.