This study presents a research methodology based on a successful e-learning model, which presents the inter-relationship between an e-learner’s characteristics and quality perception in regard to LMS (learning management systems). This research model focuses on the e-Learner’s cognitive empathy, self-regulatory efficacy, self-regulated learning strategies, and satisfaction with the learning environment. The learning environment consists of a learning management system, learning content, as well as interactions which were provided through the e-learning procedures. Based on the assumption that e-learning, as information system - its attributes, correlates with the learner’s characteristics, the study verified user-satisfaction and system’s quality to information systems. In the information systems success model, independent variables are such as an e-Learner’s cognitive empathy, self-regulated learning strategy, self-regulatory efficacy, satisfaction regarding learning content, system quality, and interactions between the teacher and learner; and the dependent variables are such as the e-Learner’s expected performance and actual performance levels through professor evaluations. This paper concludes that the e-learner’s characteristics, such as cognitive empathy and self-regulated learning strategies, are considered as important variables in respect to e-learning performance. Additionally, LMS quality is also considered to be important. The validity of this research model will be demonstrated on an empirical basis.