This study investigates the effectiveness of a teaching and learning strategy called Multimedia Project-Based Learning (MPBL) on pre-service teachers in a university setting. The main focus of this teaching and learning strategy is to enhance teachers’ communication, technology, collaborative and thinking skills. A total of 82 pre-service teachers enrolled in a semester long technology-oriented course at the College of Education at Kuwait University were involved in a pre-post assessment of skills acquisition using a survey instrument. A second survey instrument was administered to examine the pre-service teachers’ perceptions about the effectiveness of MPBL. The analysis indicates significant differences between groups in relation to the assigned indicators. Positive perceptions were expressed by pre-service teachers as a result of learning using the MPBL approach. Suggestions for designing of effective MPBL in a university setting are included.