An operational strategy for inventory control on finished goods in the distribution system has been given attention to many enterprises and many studies regarding this field have been done and is also on-going currently. Many of these studies represented a large scale distribution network with a unified formulation by using defined symbols. These methods have provided the systematic approach of the distribution network but they are impossible to applying the reality system due to not considering the service rate of demand and treating the shortage of inventory. In order to overcome these unrealistic problems, the novel safety stock policy of responding to customers' inventory distribution network is suggested. this paper explores the transportation between Central Distribution Center(CDC) and Regional Distribution Center(RDC). Especially, the relation of transportation cost between CDC and RDC and cost of inventory control according to safety inventory with service level are emphasized. We could obtain the good results of this study by determining the optimal safety stock considering the various variables and constraints.