Corporations are faced with the key strategic task of adopting a comprehensive management system of a new paradigm in order to enhance their products' quality, safety, and reliability, as well as to minimize the cost of quality. The purpose of this paper is to present a methodology that can be used by corporations to ensure a product's reliability, safety, and maintainability, with minimal costs, by measuring dependability levels and conducting DEA analysis. The methodology will be a way for corporations to adopt an optimal dependability management system based on a quality management system of ISO 9001:2000 standards.