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Cytotoxic Constituents from the Aerial Part of Clematis apiifolia L. KCI 등재
- 언어ENG
- URLhttps://db.koreascholar.com/Article/Detail/255135
한국약용작물학회지
(Korean Journal of Medical Crop Science)
Vol.14 No.5 (2006.10)
pp.299-302
pp.299-302
한국약용작물학회
(The Korean Society of Medicinal Crop Science)
초록
Three known triterpenoids were isolated from MeOH extract of C. apiifolia (Ranunculaceae). Their structures were identified as oleanolic acid (1), ursolic acid (2), hederagenic acid (3) by comparison of their physicochemical and spectral data with the literature values. Among them, 2 was isolated for the first time from this plant. The isolated compounds were evaluated for their cytotoxicity against L1210, HL-60, SK-OV-3 tumor cell lines. All compounds 1-3 were shown good activities with IC50 values ranging from 7.7 to 25.6 μg/ml. This result suggests that triterpenoids 1-3 are main cytotoxic principles of this plant.
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