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식물추출물의 Human-ACAT 저해활성 검색 KCI 등재

Screening for Human ACAT-1 and ACAT-2 Inhibitory Activity of Edible Plant Extracts

이대영, 정태숙, 류하나, 방면호, 홍윤희, 이윤형, 백남인
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  • URLhttps://db.koreascholar.com/Article/Detail/255271
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한국약용작물학회지 (Korean Journal of Medical Crop Science)
Vol.16 No.5 (2008.10)
pp.341-348
한국약용작물학회 (The Korean Society of Medicinal Crop Science)
초록

Cholesterol acyltransferase (ACAT) catalyzes the acylation of cholesterol to cholesteryl ester with long chain fatty acids and ACAT inhibition is a useful strategy for treating hypercholesterolemia or atherosclerosis. Inhibitory effects on ACAT of the MeOH extracts prepared from 163 edible plants were evaluated. 15 species out of 163 species exhibited higher than 50% of inhibition on the hACAT-1 and 9 species exhibited higher than 50% of inhibition on the hACAT-2 activity at their concentration of 100 μg/mL.

키워드
Edible PlantAcyl-CoA: Cholesterol AcyltransferaseACATHypercholesterolemiaAtherosclerosis
저자
  • 이대영 | Lee, Dae-Young
  • 정태숙 | Jeong, Tae-Sook
  • 류하나 | Lyu, Ha-Na
  • 방면호 | Bang, Myun-Ho
  • 홍윤희 | Hong, Yoon-Hee
  • 이윤형 | Lee, Youn-Hyung
  • 백남인 | Baek, Nam-In
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