항진균제로서 무화과 활성물질을 이용한 Ketoconazole 유도체 합성

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항진균제로서 무화과 활성물질을 이용한 Ketoconazole 유도체 합성 KCI 등재

The Synthesis of Ketoconazole Derivatives Using Biological Activity Compounds in Figue as an Antifungal Agents

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URLhttps://db.koreascholar.com/Article/Detail/257258

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한국응용과학기술학회지 (The Korean Society of Applied Science and Technology)

Vol.16 No.4 (1999.12)
pp.299-306

한국응용과학기술학회(구 한국유화학회) (The Korean Society of Applied Science and Technology (KSAST))

초록

For the synthesis of new antifungal agents, We have synthesized four new ketoconazole derivatives were synthesized by the reaction of cis-[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-1,3-dioxolan-4-yl]methane sulfonate with isolated fig compounds. These compounds were showed strong antifungal activity against C, albicans ATCC 10231. C, utilis. S, cerevisiae ATCC 9763. A and niger ATCC 9029. Among them, sample No.(13) showed potent inhibition activity. Generally, other samples showed biological activity in vitro test. The above results showed the possibility of the development of new antifungal agents.

키워드

The Synthesis of Ketoconazole Derivatives

저자

류성렬 | Ryu, Soung-Ryual

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