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Quinazolinylmethoxybenzene 유도체 합성 및 흑색종 세포증식 저해효능 KCI 등재
Synthesis and Antiproliferative Activity of Quinazolinylmethoxybenzene Derivatives against Melanoma Cell Line
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- URLhttps://db.koreascholar.com/Article/Detail/257763
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한국응용과학기술학회지
(The Korean Society of Applied Science and Technology)
Vol.27 No.1 (2010.03)
pp.20-28
pp.20-28
한국응용과학기술학회(구 한국유화학회)
(The Korean Society of Applied Science and Technology (KSAST))
초록
Melanoma is the most aggressive form of skin cancer and is the fastest growing type of cancer in the United States. We report here the synthesis of a novel series of quinazolinylmethoxybenzene derivatives 1a-c and their antiproliferative activities against A375 human melanoma cell line. Among them, urea compound 1a (IC50 = 4.8 μM) having 4-chloro-3-trifluoromethylphenyl moiety showed superior antiproliferative activity to Sorafenib (IC50 = 5.5 μM) as a reference compound. These results will helpful for designing structure of a therapeutic agent for the treatment of melanoma.
키워드
quinazolinylmethoxybenzenessynthesisantiproliferative activitymelanoma cell line
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