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KCI 등재
Cytochrome P-450 2A6 Inhibitor Based on the Indole Moiety
한국응용과학기술학회지
(The Korean Society of Applied Science and Technology)
Vol.29 No.3 (2012.09)
pp.435-442
pp.435-442
한국응용과학기술학회(구 한국유화학회)
(The Korean Society of Applied Science and Technology (KSAST))
초록
The cytochrome P-450 enzymes (CYP 2A6) regulate many endogenous signaling molecules and drugs. Aryl alkynes such as 2-ethynylnaphthalene are important P450 inhibitors which have been extensively studied as medicines or as an effective chemical probes for profiling mouse liver microsomal P-450. Here we have synthesized indole-based novel P450 inhibitor, 5-ethynyl indole 3, and showed that it has successfully inhibited CYP 2A6 by chemical inhibition reaction. By using HPLC equipped with a photo diode array(PDA) detector, all of the peaks derived from the enzymatic reaction have been characterized.
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