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Dietary turmeric presents mild immune suppressing and anti-inflammatory effects KCI 등재

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예방수의학회지 (Journal of Preventive Veterinary Medicine)
한국예방수의학회(구 한국수의공중보건학회) (The Korean Society of Preventive Veterinary Medicine)
초록

Pathologic chronic inflammation, such as that seen with microbial infection and autoimmune diseases, creates microenvironmental conditions that promote cancer. Therefore, if chronic inflammation can be alleviated, the risk of carcinoge- nesis may decrease. Turmeric is a dried rhizome powder from Curcuma longa. Curcumin, the major constituent of turmeric, presents anti-inflammatory, antioxidant, antimicrobial and chemopreventive activities. In the present study, we investigated immune responses to dietary turmeric in ICR mice to determine the effects of turmeric when used as a dietary chemoprevention agent. After dietary turmeric was given for three or six weeks to ICR male mice, the immune responses were characterized. The methods of characterization involved; the determination of the T cell subpopulation in the spleen, relative mRNA expression levels of IFN-γ and TNF-α and serum lysozyme activity. Dietary turmeric was found to decrease spleen weight, decrease the proportion of CD4-CD8+ T cells, and decrease phagocytic activity. These results suggest that turmeric might alleviate abnormal chronic inflammation by the action of immune suppression.

저자
  • Yun-Mi Kim(Department of Veterinary Infectious Disease, College of Veterinary Medicine, Chonnam National University)
  • Jin-A Lee(Department of Veterinary Infectious Disease, College of Veterinary Medicine, Chonnam National University)
  • Tae-Hoon Kim(Department of Veterinary Infectious Disease, College of Veterinary Medicine, Chonnam National University)
  • Bock-Gie Jung(Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center) Corresponding author
  • Bong-Joo Lee(Department of Veterinary Infectious Disease, College of Veterinary Medicine, Chonnam National University)