논문 상세보기
pp.109-115
기질 화합물로써 3β-hydroxy-12-oleanen-28-oic acid 유도체들의 치환기(R₁ ∼ R₄)가 변화함에 따른 protein tyrosine phosphatase (PTP)-1B의 저해활성에 관한 비교 분자장 분석(CoMFA) 모델을 유도하고 정량적으로 검토하였다. 최적의 CoMFA F1 모델은 가장 높은 예측성과 상관성(r²cv.=0.654 및 r²ncv.=0.995)을 나타내었다. 저해활성에 관한 CoMFA장 기여비율(%)의 순서는 입체장(53.0 %), 정전기장(36.2 %) 및 소수성장(10.8 %) 이었다. 등고도 분석 결과로부터 저해활성은 기질 분자 내 R4-치환기에 의존적이었으며 특히 melanin 저해활성이 높은 새로운 화합물(P1 및 P2)이 예측되었다.
The comparative molecular field analyses (CoMFA) models between the substituents with changing groups (R₁ ∼ R₄) of 3β-hydroxy-12-oleanen-28-oic acid derivatives as substrate molecule and their inhibitory activities (pI50) against protein tyrosine phosphatase (PTP)-1B were derived and discussed quantitatively. The optimized CoMFA F1 model have best predictability and fitness (r²cv.=0.654 and r²ncv.=0.995). The order of contribution ratio (%) with CoMFA fields on the inhibitory activities was a steric field (53.0 %), electrostatic field (36.2 %) and hydrophobic field (10.8 %). From the analytical results of CoMFA contour maps, the inhibitory activities were dependent on the R4 group in substrate molecules. Particularly, the new active compounds (P1 & P2) with the inhibitory activity against melanin synthesis were expected.
