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Efficacy of two virulence gene-deleted Salmonella Typhimurium vaccine candidate for Salmonella infections in weaning piglets KCI 등재

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예방수의학회지 (Journal of Preventive Veterinary Medicine)
한국예방수의학회(구 한국수의공중보건학회) (The Korean Society of Preventive Veterinary Medicine)
초록

We previously developed a novel attenuated Salmonella Typhimurium (S.Typhimurium) △lon△cpxR vaccine. This study was conducted in order to examine whether this vaccine could effectively protect growing piglets against Salmonella infection. Pregnant sows in group A were primed and boosted with the vaccine, whereas pregnant sows in group B received sterile PBS-sucrose. After farrowing, newborn piglets in groups A and B were challenged with a wild type virulent S. Typhimurium at three weeks of age. During the study, serum IgG titers of piglets in group A were significantly higher than those of piglets in group B (P<0.001). In addition, clinical signs were observed in 5.9% of piglets in group A during the entire experimental period after the challenge, while diarrhea was observed in 81.6% of piglets in group B. These results indicate that vaccination of the pregnant sows resulted in effective protection in piglets against Salmonella infection.

저자
  • John Hwa Lee(College of Veterinary Medicine, Chonbuk National University)
  • Yeong Hwan Choi(Chungcheongnam-Do Livestock Technology Research Institute)
  • Min Su Choi(College of Veterinary Medicine, Chonbuk National University)
  • Jin Hur(College of Veterinary Medicine, Chonbuk National University) Corresponding author