The cross-sexual movement in ads implies that a gender role stereotype that was not easily changed in society has been steadily changed lately. In general, changes happen after a phenomenon. If the cross-sexual trend in ads brings about changes in the society of eastern culture where a gender role stereotype is relatively stronger than western culture, the social impact of cross-sexual advertising will be quite influential. From such perspective, this study attempted to empirically validate the effect of cross-sexual advertising which many companies are now utilizing increasingly. Specifically, this study was intended to identify the boundary conditions for the effect of cross-sexual advertising. This study validated the moderating effect of consumers' self-construal and need-for-uniqueness on the relationship between the ad type and the consumer evaluation. Furthermore, it clarified what the underlying cognitive mechanism was for the effect of cross-sexual ads.