This study was carried out to obtain new anti-gout agent from mushrooms. Various extracts from twelve kinds of mushrooms were prepared by water and ethanol extractions and its anti-gout xanthine oxidase inhibitory activity were investigated. Water extract of Flammulina velutipes and Agaricus bisporus fruiting bodies showed high xanthine oxidase inhibitory activity of 70.8% and 60.0%, respectively. However, its inhibitory activity of these ethanol extracts were very low excepet 60.3% of Innotus obliquus. Finally, we selected Flammulina velutipes, showing the highest xanthine oxidase inhibitory activity as a producer of new anti-gout agent.

• Jung-Hwa Song(Department of Life Science and Genetic Engineering, Paichai University, Daejeon 302-735, Korea)
• Bolormaa Zanabaatar( Department of Life Science and Genetic Engineering, Paichai University, Daejeon 302-735, Korea) | Bolormaa Zanabaatar
• Jeong-Hoon Jang( Department of Life Science and Genetic Engineering, Paichai University, Daejeon 302-735, Korea) | Jeong-Hoon Jang
• Hyung-Jun Noh( National Institute of Agricultural Science and Technology, Suwon 441-707, Korea) | Hyung-Jun Noh
• Young-Bok Yoo( National Institute of Agricultural Science and Technology, Suwon 441-707, Korea) | Young-Bok Yoo
• Jong-Soo Lee( Department of Life Science and Genetic Engineering, Paichai University, Daejeon 302-735, Korea) | Jong-Soo Lee