Spatial structures have the different dynamic characteristics from general rahmen structures. Therefore, it is necessary to accurately analyze dynamic characteristics and seismic response of spatial structure for seismic design of spatial structure. An arch structure is used as an example structure because it has primary characteristics of spatial structures. Multiple support excitation may be subjected to supports of a spatial structure because ground condition of spatial structures is different. In this study, the response analysis of the arch structure under multiple support excitation and simple support excitation is studied. By means of the pseudo excitation method, the seismic response is analyzed for long span spatial structure. It shows that the structural response is divided into two parts, ground displacement and structural dynamic response due to ground motion excitation. It is known that the seismic response of spatial structure under multiple support excitation and simple support excitation are the different in some case. Therefore, it has to be necessary to analyze the seismic response of spatial structure under multiple support excitation because the spatial structure supports may be different.