To determine whether S-(-)-10,11-dihydroxyfarnesic acid methyl ester (DHFAME) produced by Beauveria bassiana CS1029 potentially causes acute skin irritation as a cosmetic ingredient, a skin toxicity test was conducted as recommended for compliance with Korea Food and Drug Administration regulations. New Zealand White rabbits were treated with 100 mg/dose of DHFAME according to standard guidelines. No significant skin lesions or inflammation was observed in the DHFAME-treated group. Furthermore, DHFAME did not appear to cause skin irritation, as assessed by clinical observation of the rabbits. Thus, when taken together, the present results suggest that DHFAME is a promising potential cosmetic ingredient that does not irritate the skin.

 Abstract  Introduction  Materials and Methods   Animals and care   Isolation and preparation of test material   Skin irritation test   Analysis of skin irritation  Results and Discussion  Summary  References

• Kim, Min-A(Department of Food Science & Biotechnology)
• Lee, Sang-Han( Department of Food Science & Biotechnology, Food & Bio-Industry Research Institute, Kyungpook National University) | Lee, Sang-Han