Base isolation is considered as a seismic protective system in the design of next generation Nuclear Power Plants (NPPs). If seismic isolation devices are installed in nuclear power plants then the safety under a seismic load of the power plant may be improved. However, with respect to some equipment, seismic risk may increase because displacement may become greater than before the installation of a seismic isolation device. Therefore, it is estimated to be necessary to select equipment in which the seismic risk increases due to an increase in the displacement by the installation of a seismic isolation device, and to perform research on the seismic performance of each piece of equipment. In this study, modified NRC-BNL benchmark models were used for seismic analysis. The numerical models include representations of isolation devices. In order to validate the numerical piping system model and to define the failure mode, a quasi-static loading test was conducted on the piping components before the analysis procedures. The fragility analysis was performed by using the results of the inelastic seismic response analysis. Inelastic seismic response analysis was carried out by using the shell finite element model of a piping system considering internal pressure. The implicit method was used for the direct integration time history analysis. In addition, the collapse load point was used for the failure mode for the fragility analysis.