It is important to develop the smart ventilation system in order to minimize a building energy consumption using ventilation. In this study, We evaluated the efficiency of the smart ventilation system being developed at the nursery. To evaluate the energy savings and carbon dioxide removal efficiency, two kinds of experimental conditions were compared. First, air conditioner and Smart HVAC system were operated. Second, air conditioner was operating and external air was put into the inside by rate of air circulation. It was more effective when working with air conditioning and ventilation system at the same time. If the Smart HVAC system is applied in a multi-use facility, indoor air quality will be comfortable and the social cost will be reduced.