Angiogenesis is a process with a coordinated sequence of endothelial cell division, selective degradation of vascular basement membranes, and surrounding extracellular matrix with migration of theses cells that result in a new capillary growth from preexisting vessels. These processes are controlled by numerous different molecules. Among these, Vascular Endothelial Growth Factor(VEGF) is an endothelial cell-specific mitogen with a potent ability to induce microvessel permeability and angiogenesis. In this study, tissue samples of odontogenic keratocyst(10 cases), ameloblastoma(10 cases), adenomatoid odontogenic tumor(10 cases), calcifying epithelial odontogenic tumor(10 cases), ameloblastic carcinoma(2 cases) were obtained, and all specimen were routinely fixed in 10% formalin and embedded. Serial 5μm thick sections were cut from paraffin blocks. And the immunohistochemical staining, characteristics of VEGF about the cyst & tumor were observed & obtaned the results from this study. We presume that the growth of cyst is depends on not a differentiation but an epithelium & connective tissue. But, in odontogenic tumor, we presumed that the growth of tumor is influenced on inflammation & surrounding stimulus & vascular growth and supply. Therefore, it should be suggested that study on the growth of tumor and vascularity must be carrying out in this immunohistochemical study.

I. 서론
 II. 연구 재료 및 방법
  1. 조직표본
  2. 면역조직화학적 염색
  3. 평가방법
 III. 연구 결과
  1) OKC(치성각화낭종)의 Anti-VEGF 반응 검사결과
  2) Ameloblastoma(법랑모세포종)의 Anti-VEGF 반응검사결과
  3) AOT(선양치성종양)의 Anti-VEGF 반응 검사결과
  4) CEOT(석회화상피성 치성종양)의 Anti-VEGF 반응검사결과
  5) Ameloblastic Carcinoma(법랑모세포 암종)의 Anti-VEGF 반응 검사결과
 IV. 총괄 및 고찰
 V. 결론
 VI. 참고문헌

• 황대용(단국대학교 치과대학 구강외과학교실) | Dae Yong Hwang
• 이재훈(단국대학교 치과대학 구강외과학교실) | Jae Hoon Lee correspondence