Central granular cell odontogenic tumor (CGCOT) is a rare benign odontogenic neoplasm, with approximately 30 cases having been reported. The pathogenesis of CGCOT as well as the designation of this lesion is controversial because of unknown histogenesis of the granular cell. We present an additional case of CGCOT involving the mandible of a 50-year-old Korean man who complained of asymptomatic swelling of the right buccal gingiva. Current lesion is microscopically characterized by densely packed polyhedral granular cells surrounding interspersed islands or strands of odontogenic epithelium. Immunohistochemically, granular cells were positive for Vimentin and CD68, and negative for cytokeratin and S-100. These features support a mesenchymal origin for the granular cells as other results previously reported.

• 윤혜정(서울대학교 치의학대학원 구강병리학교실) | Hye Jung Yoon
• 최소영(서울대학교 치의학대학원 구강병리학교실) | So Young Choi
• 홍성두(서울대학교 치의학대학원 구강병리학교실) | Seong Doo Hong
• 홍삼표(서울대학교 치의학대학원 구강병리학교실) | Sam Pyo Hong
• 이재일(서울대학교 치의학대학원 구강병리학교실) | Jae Il Lee correspondence