An efficient and practical reliability analysis method is required for the development of reliability-based design (RBD) guidelines of coastal structures. Such a novel method is presented in this paper. It is capable of evaluating reliability of real complicated coastal structures considering uncertainties in various sources of design parameters. It is developed by intelligently integrating the Latin hypercube sampling (LHS) method and the finite element method (FEM). The applicability and efficiency of the proposed method are verified using a caisson-type quay wall. in the numerical example.